Relação da osteonecrose dos maxilares associada a medicamentos (OMAM) com a reabilitação oral implantosuportada: revisão integrativa da literatura

Abstract

Antiresorptive and antiangiogenic drugs, in addition to their expected pharmacological action, may produce undesirable, severe side effects. Bisphosphonates, for instance, are potent osteoclast inhibitors used in the treatment of bone malignancies, osteoporosis and osteopenia. These drugs act on bone resorption and can influence oral rehabilitation with dental implants if a side such as medication-related osteonecrosis of the jaws (MRONJ) arises. This study is an integrative review of the scientific literature concerning the use of dental implants in patients receiving drugs that can induce MRONJ with the intention of providing the clinician with guidance on how to best manage such cases. Based on the findings and on the experiences reported, it appears that implant placement in patients receiving antiresorptive and antiangiogenic drugs is not absolutely contraindicated, provided that a clinical treatment protocol is delivered in a thoughtful, individualized manner.