Impacto do projeto coala em desfechos clínicos de pacientes prematuros em duas maternidades de Sergipe

Abstract

The most used drug in neonatal intensive care is oxygen which demands a controlled use to prevent damage to premature newborns. The Coala Project (Controlling Target Oxygen Actively) aims to control the inspiratory fraction of oxygen according to a specific adjustment protocol to reach the target saturation of 91%-95%. Observing the importance of this clinical practice for premature, it will be evaluated the impact of the Coala Project on the main clinical outcomes in two maternity hospitals in Sergipe, one in the private sector and the other in the public sector. Two groups will be observed. The first one without clinical intervention and the second one with the implementation of the Coala Project. It will be assessed the most common outcomes in preterm that are related to hyperoxia: retinopathy of prematurity, pulmonary bronchodysplasia; and hypoxia: necrotizing enterocolitis and deaths. The level of significance of the analyzes was 5%, using mean-median, standard deviation and absolute and relative percentage frequency in descriptive statistics and the tests used were Chi-square, Fisher's exact and Mann-Whitney in the inferences. The Informed Consent Form must be signed by the parents or guardians of the patients. In August 2020, fifty-five members of the clinical staff were trained how to control the oxygen supply. One hundred premature were included in the study. Regarding retinopathy of prematurity and bronchopulmonary dysplasia, there were a significant difference in harm reduction, with p<0,01. About deaths, there was a reduction in cases in absolute numbers. No positive comments were published on the necrotizing enterocolitis outcome, but an increase in the absolute number of cases.