Efeito do extrato aquoso da Hyptis pectinata sobre a proliferação de hepatócitos após hepatectomia parcial

Abstract

Objective - The use of medicinal plants has increased worldwide. Therefore, it is necessary to know their possible effects in order to establish their correct use on human beings. Taking it into account, the objective of this study was to assess the effects of the aqueous extract of Hyptis pectinata leaves, popularly known as “sambacaitá” or “canudinho”, on liver regeneration after partial hepatectomy in rats. Methods - Ten rats were divided into 2 groups: HP group, which underwent 67% hepatectomy after 4 days of distilled water administration; and HP100 group, which was submitted to partial hepatectomy and oral administration of 100 mg/kg of the aqueous extract of Hyptis pectinata for the same period of time. All animals were sacrificed 24 hours after the surgical procedure. Liver regeneration was evaluated by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) using the PC10 monoclonal antibody. Results - The hepatic regeneration index was significantly increased in HP100 group (p<0.05). Conclusions - The present study shows that the aqueous extract of Hyptis pectinata leaves can stimulate liver regeneration at 100 mg/kg.