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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/20328
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dc.contributor.authorConde Garcia, Eduardo Antonio-
dc.contributor.authorNascimento, Vanessa Tavares do-
dc.contributor.authorSantos, Angela Barreto Santiago-
dc.date.accessioned2024-10-24T23:58:13Z-
dc.date.available2024-10-24T23:58:13Z-
dc.date.issued2003-
dc.identifier.citationCONDE GARCIA, E. A.; NASCIMENTO, V. T.; SANTOS, A. B. S. Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 36, n. 5, p. 661-668, maio 2003. Disponível em: https://www.scielo.br/j/bjmbr/a/zZWPRh3QRtRWGhy7Nr3TTbH/?format=pdf&lang=en. Acesso em: 24 out. 2024.pt_BR
dc.identifier.issn0100-879X-
dc.identifier.issn1414-431X-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/20328-
dc.languageengpt_BR
dc.publisherAssociação Brasileira de Divulgação Científicapt_BR
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchpt_BR
dc.subjectHeart contractilityeng
dc.subjectGuinea pigeng
dc.subjectMyocardial inotropismeng
dc.subjectPsidium guajava L.eng
dc.subjectFolk medicineeng
dc.subjectContratilidade miocárdicapor
dc.titleInotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atriumpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoMany pharmacological effects have been ascribed to extracts of Psidium guajava L. (guava) leaves. However, in spite of its widespread use in Brazilian folk medicine and a reasonable number of scientific reports about it, we could not find any study dealing with its action on the mammalian myocardium. In the present study, by measuring isometric force, we observed that the crude extract of P. guajava (water-alcohol extract obtained by macerating dry leaves) depresses the guinea pig atrial contractility in a concentration-dependent fashion (N = 8 hearts, 15 trials). The compound with cardiac activity was concentrated by extraction in a Soxhlet apparatus using 17 M glacial acetic acid after removing the less polar fractions (hexane, chloroform, acetone, ethanol and methanol), suggesting that this compound is a highly polar substance. In the isolated guinea pig left atrium the acetic acid fraction (10-800 mg/l) of P. guajava 1) reversibly decreased myocardial force in a concentration-dependent fashion (EC50 = 0.07g/l, N = 5 hearts, 9 trials, P<0.05), 2) increased the atrial relaxation time measured at 20% of the force amplitude up to 35% (91 ± 15 to 123 ± 30 ms, N = 3 hearts, 6 trials, P<0.05), 3) abolished the positive staircase effect (Bowditch phenomenon) in a concentration-dependent fashion suggesting a decrease of the cellular inward calcium current (N = 4 hearts, 8 trials, P<0.05), and 4) its inotropic effect was abolished by cholinergic receptor blockade with 1.5 mM atropine sulfate, indicating a cholinergic involvement in the mechanism of action of the extract (N = 7 hearts, 15 trials, P<0.05). The acetic acid extract was 20 times more potent than crude extract (EC50 = 1.4 g/l). The results showed that extracts from P. guajava leaves depress myocardial inotropism.pt_BR
dc.description.localRibeirão Pretopt_BR
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