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dc.contributor.authorLopes, Heno Ferreira-
dc.contributor.authorConsolim-Colombo, Fernanda Marciano-
dc.contributor.authorBarreto-Filho, José Augusto Soares-
dc.contributor.authorRiccio, Grazia Maria Guerra-
dc.contributor.authorNegrão, Carlos Eduardo-
dc.contributor.authorKrieger, Eduardo Moacyr-
dc.date.accessioned2025-01-27T19:42:51Z-
dc.date.available2025-01-27T19:42:51Z-
dc.date.issued2008-10-
dc.identifier.citationLOPES, H. F. et al. Increased sympathetic activity in normotensive offspring of malignant hypertensive parents compared to offspring of normotensive parents. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 41, n. 10, p. 849-853, out. 2008. Disponível em: https://www.scielo.br/j/bjmbr/a/ZMH9LyZ9TYhWqg9bbMThqsd/?format=pdf. Acesso em: 27 jan. 2025.pt_BR
dc.identifier.issn0100-879X-
dc.identifier.issn1414-431X-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/20884-
dc.languageengpt_BR
dc.publisherAssociação Brasileira de Divulgação Científicapt_BR
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchpt_BR
dc.subjectMalignant hypertensioneng
dc.subjectOffspring of malignant hypertensive parentseng
dc.subjectSympathetic activityeng
dc.subjectMicroneurographyeng
dc.subjectMicroneurografiapor
dc.titleIncreased sympathetic activity in normotensive offspring of malignant hypertensive parents compared to offspring of normotensive parentspt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoMalignant hypertension seems to be the consequence of very high blood pressure. Furthermore, an increase in sympathetic and renin-angiotensin system activity is considered to be the main mechanisms producing malignant hypertension. In the present study, 10 offspring of malignant hypertensive (OMH) parents (age 28 ± 5 years, 7 males, 3 females, 2 white and 8 non-white) and 10 offspring of normotensive (ONT) parents (age 28 ± 6 years, 2 males, 8 females, 3 white and 7 non-white) were evaluated. The OMH group had significantly higher (P < 0.05) casual blood pressure (125 ± 10/81 ± 5 mmHg) compared with ONT (99 ± 13/67 ± 5 mmHg). The increase in blood pressure was greater in OMH (Δ SBP = 17 ± 2 vs Δ SBP = 9 ± 1 mmHg in ONT) during cold pressor testing, but they had a lower increase in heart rate (Δ HR = 13 ± 2 vs Δ HR = 20 ± 3 bpm in ONT) during isometric exercise (handgrip test). Sympathetic activity, measured by microneurography, was significantly higher (P < 0.05) before exercise in OMH (17 ± 6 vs 11 ± 4 burst/min in ONT) and exhibited a greater increase (Δ = 18 ± 10 vs Δ = 8 ± 3 burst/min in ONT) during isometric exercise. This study showed increased sympathetic activity in OMH before exercise and a greater response during isometric exercise, suggesting an autonomic abnormality before exercise and a greater sympathetic response to physical stress in OMH compared to ONT.pt_BR
dc.description.localRibeirão Pretopt_BR
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