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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/21506
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dc.contributor.authorMoura, Tatiana Rodrigues de-
dc.contributor.authorOliveira, Fabiano-
dc.contributor.authorRodrigues, Gabriele Costa-
dc.contributor.authorCarneiro, Marcia Weber-
dc.contributor.authorFukutani, Kiyoshi Ferreira-
dc.contributor.authorNovais, Fernanda Oliveira-
dc.contributor.authorMiranda, José Carlos-
dc.contributor.authorBarral-Netto, Manoel-
dc.contributor.authorBrodskyn, Claudia-
dc.contributor.authorBarral, Aldina-
dc.contributor.authorOliveira, Camila Indiani de-
dc.date.accessioned2025-04-01T11:30:41Z-
dc.date.available2025-04-01T11:30:41Z-
dc.date.issued2010-06-
dc.identifier.citationMOURA, T. R. et al. Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis. PLoS Neglected Tropical Diseases, v. 4, n. 6, jun. 2010. Disponível em: https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000712&type=printable. Acesso em: 1 abr. 2025.pt_BR
dc.identifier.issn1935-2727-
dc.identifier.issn1935-2735-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/21506-
dc.languageengpt_BR
dc.publisherPublic Library of Science (PLOS)pt_BR
dc.relation.ispartofPLoS Neglected Tropical Diseasespt_BR
dc.subjectImmunityeng
dc.subjectLutzomyia intermediaeng
dc.subjectLeishmania braziliensiseng
dc.titleImmunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensispt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoBackground: During blood feeding, sand flies inject Leishmania parasites in the presence of saliva. The types and functions of cells present at the first host-parasite contact are critical to the outcome on infection and sand fly saliva has been shown to play an important role in this setting. Herein, we investigated the in vivo chemotactic effects of Lutzomyia intermedia saliva, the vector of Leishmania braziliensis, combined or not with the parasite. Methods and Findings: We tested the initial response induced by Lutzomyia intermedia salivary gland sonicate (SGS) in BALB/c mice employing the air pouch model of inflammation. L. intermedia SGS induced a rapid influx of macrophages and neutrophils. In mice that were pre-sensitized with L. intermedia saliva, injection of SGS was associated with increased neutrophil recruitment and a significant up-regulation of CXCL1, CCL2, CCL4 and TNF-a expression. Surprisingly, in mice that were pre-exposed to SGS, a combination of SGS and L. braziliensis induced a significant migration of neutrophils and an important modulation in cytokine and chemokine expression as shown by decreased CXCL10 expression and increased IL10 expression. Conclusion: These results confirm that sand fly saliva modulates the initial host response. More importantly, pre-exposure to L. intermedia saliva significantly modifies the host’s response to L. braziliensis, in terms of cellular recruitment and expression of cytokines and chemokines. This particular immune modulation may, in turn, favor parasite multiplication.pt_BR
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