Clearance de Creatinina sérica como marcador de prognóstico e fator preditor nas síndromes coronarianas agudas (SCA): Registro SOLAR

Abstract

Chronic kidney disease (CKD) affects about 10% to 13% of the world population, and the association between CKD and cardiovascular events is well documented. However, cardiovascular risk scores are little used in the study of renal function as a predictive and prognostic factor in acute coronary syndromes. OBJECTIVE: To evaluate serum creatinine clearance by means of glomerular filtration rate (GFR) as a prognostic marker and predictor of major cardiovascular event (MCE) in late follow-up of patients with ACS. METHODS: Prospective cohort analysis of the charts of 154 patients diagnosed with ACS and with GFR calculated at admission to the emergency department. Intra- and extra-hospital evolutions and MCE occurrence were observed within. RESULTS: 84 patients (54.5%) had GFR <90 ml / min / 1.73 m2. In the hospital evolution, acute pulmonary edema was more frequent in patients with reduced GFR (13.09% vs. 1.4%, p = 0.0196). After hospital discharge, the occurrence of the composite endpoint for ECM was significantly higher in the group with reduced GFR when compared to the group with normal GFR (19.04% vs. 6.71%, p=0.0062). CONCLUSION: GFR is an important predictive factor for ECD at 01 year, as well as an important marker of severity for ischemic events and, consequently, a marker of prognosis for such events.