Fatores relacionados à mortalidade em pacientes pediátricos com neutropenia febril

Abstract

Objetive: To evaluate the association between factors related to Febrile Neutropenia and mortality in pediatric patients undergoing chemotherapy. Methods: Cross-sectional study, conducted between July 2014 and June 2015, enrolling patients undergoing chemotherapy in a regional reference oncology hospital, which belongs to a general hospital in northeastern Brazil. Data were obtained from a standard questionnaire and medical records. The questionnaire, answered by patients' parents, included: sociodemographic and clinical characteristics of the patients, diagnosis, onset of fever schedules, time of hospital arrival and onset of antibiotics, the episode duration of febrile neutropenia and outcome. Data were analyzed by SPSS software version 16.0. Results: The study included 54 patients diagnosed with cancer with febrile neutropenia, with a mean age of 8,54 years, and 72,2% were male. Among patients, 55,6% had acute lymphocytic leukemia diagnosis. There was a statistically significant difference between the groups with outcome of death or not when compared with the presence of central venous catheter (p=0,016). Conclusions: The central venous catheter use factor was related to death outcome in the studied sample, which suggests greater care in the clinical management with the use of prophylactic antibiotics and earlier intervention in the fever presence.