Distribuição da gordura corporal em indivíduos com deficiência isolada do hormônio de crescimento

Abstract

Objectives: To evaluate body composition by DXA, comparing the distribution of central and peripheral fat in adults with GHD homozygous mutation of GHRH-R and normal controls. Materials and methods: We measured by DXA fat mass and total lean and regional appliance using the Lunar ( GE ) DPX / MT in 23 subjects from group Digh and 21 control subjects . Results: He data showed that between the percentage of fat and lean mass did not differ. Android fat was higher in affected individuals compared to control (p <0.01), as opposed to gynoid fat with no significant difference between groups. The rate of fat android / gynoid was also higher in the affected group compared to control (p <0.001), demonstrating greater truncal adiposity in individuals with GHD. Conclusion: A deficiency of growth hormone by GHRH-R mutation is associated with truncal adiposity, and other cardiovascular risk factor, although not observed increased mortality from ischemic heart disease or coronary artery disease in this population.