Tumor neuroectodérmico melanótico da infância dos maxilares: revisão de literatura casuística e relato de caso com caracterização imunohistoquímica, com preservação de 10 anos

Abstract

The melanocytic neuroectodermal tumor of childhood (TNMI) of the jaws is a benign neoplasm, although it presents despite its clinical manifestations power that mimic aspects of malignancy. It has its origin TNMI arises from cells of the neural crest and affects mainly children in their first year of life, the maxilla being their main area of predilection. Clinically, it is characterized as a sessile mass, painless and pigmented, and can reach large proportions that lead to facial deformations. The knowledge about its clinical characteristics helps not to undergo the correct diagnosis of the lesion, but also in the choice of the best therapeutic behavior, thus allowing for more conservative surgical interventions. Thus, the present study aims to review the cases of TNMI treated and biopsied in the Department of Dentistry of the Federal University of Sergipe (UFS), characterizing them by means of immunohistochemical marking (IHC). For that, a review of the biopsy records of the Department was carried out, between the years of 2008 and 2018, and subsequent analysis of the IHQ mean after. The IHQ study was conducted through the approval of the local ethics committee. A single case of TNMI, diagnosed in 2009. The clinical and histopathological data of the case were reviewed and in the result of IHC the cells showed suggested immunopositivity for the HMB-45, S-100 and low marking percentages for Ki -67. The results These data confirm the rarity of TNMI of the jaws and the IHQ analysis markings are compatible with those described in the literature previously. The absence of relapse of the tumor studied after a follow-up of almost 10 years of the patient, is also in agreement with the characteristics of the tumor cells, which showed a low rate of cellular proliferation.