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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/23318
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dc.contributor.authorSá, Pedro Guilherme Sousa de-
dc.contributor.authorNunes, Xirley Pereira-
dc.contributor.authorLima, Julianeli Tolentino de-
dc.contributor.authorSiqueira Filho, José Alves de-
dc.contributor.authorFontana, André Paviotti-
dc.contributor.authorQuintans, Jullyana de Souza Siqueira-
dc.contributor.authorQuintans Júnior, Lucindo José-
dc.contributor.authorDamasceno, Patrícia Kauanna Fonseca-
dc.contributor.authorBranco, Carla Rodrigues Cardoso-
dc.contributor.authorBranco, Alexsandro-
dc.contributor.authorAlmeida, Jackson Roberto Guedes da Silva-
dc.date.accessioned2025-09-29T18:31:18Z-
dc.date.available2025-09-29T18:31:18Z-
dc.date.issued2012-
dc.identifier.citationSÁ, P. G. S. et al. Antinociceptive effect of ethanolic extract of Selaginella convoluta in mice, BioMed Central complementary medicine and therapies, London, v. 12, n. 187, 2012. Disponível em: https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-12-187#article-info. Acesso em: 29 set. 2025.pt_BR
dc.identifier.issn2662-7671-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/23318-
dc.languageengpt_BR
dc.publisherBioMed Centralpt_BR
dc.relation.ispartofBioMed Central complementary medicine and therapiespt_BR
dc.subjectSelaginella convolutaeng
dc.subjectSelaginellaceaeeng
dc.subjectAnalgesiceng
dc.subjectPaineng
dc.titleAntinociceptive effect of ethanolic extract of Selaginella convoluta in micept_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 2.0 Genérica (CC BY 2.0)pt_BR
dc.description.resumoBackground: Selaginella convoluta (Arn.) Spring (Selaginellaceae), commonly known as “jericó”, is a medicinal plant found in northeastern Brazil. S. convoluta is used in folk medicine as an antidepressant, aphrodisiac, diuretic, analgesic, anti-inflammatory and it is used to combat amenorrhea, coughing and bleeding. This study was performed to evaluate the antinociceptive effects of ethanolic extract from S. convoluta in mice exposed to chemical and thermal models of nociception. Methods: Preliminary phytochemical analysis of the ethanolic extract was performed. The ethanolic extract from Selaginella convoluta (Sc-EtOH) was examined for its intraperitoneal (i.p.) antinociceptive activity at the doses of 100, 200 and 400 mg/kg body weight. Acetic acid-induced writhing, formalin injection and hot plate tests were used to evaluate the antinociceptive activity of Sc-EtOH extract. The rota-rod test was used to evaluate motor coordination. Results: A preliminary analysis of Sc-EtOH revealed that it contained phenols, steroids, terpenoids and flavonoids. In the acetic acid-induced writhing test, mice treated with Sc-EtOH (100, 200 and 400 mg/kg, i.p.) exhibited reduced writhing (58.46, 75.63 and 82.23%, respectively). Secondly, Sc-EtOH treatment (100, 200 and 400 mg/kg, i.p.) decreased the paw licking time in mice during the first phase of the formalin test (by 44.90, 33.33 and 34.16%, respectively), as well as during the second phase of the test (by 86.44, 56.20 and 94.95%, respectively). Additionally, Sc-EtOH treatment at doses of 200 and 400 mg/kg increased the latency time in the hot plate test after 60 and 90 minutes, respectively. In addition, Sc-EtOH did not impair motor coordination. Conclusion: Overall, these results indicate that Sc-EtOH is effective as an analgesic agent in various pain models. The activity of Sc-EtOH is most likely mediated via the inhibition of peripheral mediators and central inhibitory mechanisms. This study supports previous claims of traditional uses for S. convoluta.pt_BR
dc.description.localLondonpt_BR
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