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dc.contributor.authorFarias Junior, Paulo A.-
dc.contributor.authorRios, Marcos Cardoso-
dc.contributor.authorMoura, Tauanny A.-
dc.contributor.authorAlmeida, Roque Pacheco de-
dc.contributor.authorAlves, Pericles Barreto-
dc.contributor.authorBlank, Arie Fitzgerald-
dc.contributor.authorFernandes, Roberta Pereira Miranda-
dc.contributor.authorScher, Ricardo-
dc.date.accessioned2025-10-06T19:58:22Z-
dc.date.available2025-10-06T19:58:22Z-
dc.date.issued2012-
dc.identifier.citationFARIAS JUNIOR, P. A. et al. Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham. Biological Research, Santiago, v. 45, n. 4, p. 399-402, 2012. Disponível em: https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400012&lng=en&nrm=iso&tlng=en. Acesso em: 6 out. 2025.pt_BR
dc.identifier.issn0716-9760-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/23356-
dc.languageengpt_BR
dc.publisherSociedad de Biología de Chilept_BR
dc.relation.ispartofBiological Researchpt_BR
dc.subjectCarvacroleng
dc.subjectP-cymeneeng
dc.subjectEssential oil compositioneng
dc.subjectLeishmania chagasieng
dc.subjectLippia sspeng
dc.subjectThymoleng
dc.subjectVerbenaceaeeng
dc.titleLeishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Champt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0)pt_BR
dc.description.resumoLeishamaniasis is a disease that aff ects more than 2 million people worldwide, whose causative agent is Leishmania spp. The current therapy for leishmaniasis is far from satisfactory. All available drugs, including pentavalent antimony, require parenteral administration and are potentially toxic. Moreover, an increase in clinical resistance to these drugs has been reported. In this scenario, plant essential oils used traditionally in folk medicine are emerging as alternative sources for chemotherapeutic compounds. In this study, in vitro leishmanicidal eff ects of a thymol- and a carvacrol-rich essential oil from leaves of Lippia sidoides Cham. were investigated. The essential oils were extracted and their constituents were characterized by gas chromatography coupled to mass spectrometry (GC/MS). Both essential oils showed signifi cant activity against promastigote forms of Leishmania chagasi. However, we found that carvacrol-rich essential oil was more eff ective, with IC50/72 h of 54.8 μg/mL compared to 74.1 μg/mL for thymol-rich oil. Carvacrol also showed lower IC50 than thymol. Our data suggest that L. sidoides essential oils are indeed promising sources of leishmanicidal compounds.pt_BR
dc.description.localSantiagopt_BR
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DFS - Artigos de periódicos
DME - Artigos de periódicos
DMO - Artigos de periódicos
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