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Document Type:	Artigo
Title:	Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents
Authors:	Konrad, Signorá Peres Farah, Vera Rodrigues, Bruno Wichi, Rogério Brandão Machado, Ubiratan Fabres Lopes, Heno Ferreira Schaan, Beatriz D’Agord Angelis, Kátia de
Issue Date:	2012
Resumo :	OBJECTIVES: The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life. METHOD: The animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks after birth, arterial and venous catheters were implanted for arterial pressure measurements, drug administration, and blood sampling. Baroreflex sensitivity was evaluated according to the tachycardic and bradycardic responses induced by sodium nitroprusside and phenylephrine infusion, respectively. Sympathetic and vagal effects were determined by administering methylatropine and propranolol. RESULTS: Body weight, Lee index, and epididymal white adipose tissue values were higher in the monosodium glutamate group in comparison to the control group. The monosodium glutamate-treated rats displayed insulin resistance, as shown by a reduced glucose/insulin index (-62.5%), an increased area under the curve of total insulin secretion during glucose overload (39.3%), and basal hyperinsulinemia. The mean arterial pressure values were higher in the monosodium glutamate rats, whereas heart rate variability (.7 times), bradycardic responses (.4 times), and vagal (,38%) and sympathetic effects (,36%) were reduced as compared to the control group. CONCLUSION: Our results suggest that obesity induced by neonatal monosodium glutamate treatment impairs cardiac autonomic function and most likely contributes to increased arterial pressure and insulin resistance.
Keywords:	Monosodium glutamate Obesity Insulin resistance Arterial pressure Autonomic function
ISSN:	1807-5932
Is part of:	Clinics
Language:	eng
Publisher / Institution :	Faculdade de Medicina da Universidade de São Paulo
Citation:	KONRAD, S. P. et al. Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents. Clinics, São Paulo, v. 67, n. 10, p. 1209-1214, 2012. Disponível em: https://www.sciencedirect.com/science/article/pii/S1807593222022244?via%3Dihub. Acesso em: 8 out. 2025.
License:	Creative Commons Atribuição-NãoComercial 3.0 Não Adaptada (CC BY-NC 3.0)
URI:	https://ri.ufs.br/jspui/handle/riufs/23389
Appears in Collections:	DEF - Artigos de periódicos

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