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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/23442
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dc.contributor.authorObreli Neto, Paulo Roque-
dc.contributor.authorNobili, Alessandro-
dc.contributor.authorLyra Júnior, Divaldo Pereira de-
dc.contributor.authorPilger, Diogo-
dc.contributor.authorGuidoni, Camilo Molino-
dc.contributor.authorBaldoni, André de Oliveira-
dc.contributor.authorCruciol-Souza, Joice Mara-
dc.contributor.authorFreitas, Ana Luiza de Carvalho-
dc.contributor.authorTettamanti, Mauro-
dc.contributor.authorGaeti, Walderez Penteado-
dc.contributor.authorCuman, Roberto Kenji Nakamura-
dc.date.accessioned2025-10-13T17:51:01Z-
dc.date.available2025-10-13T17:51:01Z-
dc.date.issued2012-
dc.identifier.citationOBRELI NETO, P. R. et al. Incidence and predictors of adverse drug reactions caused by drug-drug interactions in elderly outpatients: a prospective cohort study. Journal of Pharmacy and Pharmaceutical Sciences, Alberta, v. 15, n. 2, p. 332-343, 2012. Disponível em: https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/17049/13684. Acesso em: 13 out. 2025.pt_BR
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/23442-
dc.languageengpt_BR
dc.publisherCanadian Society for Pharmaceutical Sciencept_BR
dc.relation.ispartofJournal of Pharmacy and Pharmaceutical Sciencespt_BR
dc.subjectDrug-drug interactionspor
dc.subjectAdverse drug reactionspor
dc.subjectElderly outpatientspor
dc.titleIncidence and predictors of adverse drug reactions caused by drug-drug interactions in elderly outpatients: a prospective cohort studypt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição-CompartilhaIgual 4.0 Internacional (CC BY-SA 4.0)pt_BR
dc.identifier.licenseLicense compatibility wizard from CC Taiwan-
dc.description.resumoPurpose: The primary objective of this study was to investigate the incidence of drug-drug interactions (DDIs) related to adverse drug reactions (ADRs) in elderly outpatients who attended public primary healthcare units in a southeastern region of Brazil. The secondary objective was to investigate the possible predictors of DDI-related ADRs. Methods: A prospective cohort study was conducted between November 1, 2010, and November 31, 2011, in the primary public healthcare system in the Ourinhos micro-region in Brazil. Patients who were at least 60 years old, with at least one potential DDI, were eligible for inclusion in the study. Eligible patients were assessed by clinical pharmacists for DDI-related ADRs for 4 months. The causality of DDI-related ADRs was assessed independently by four clinicians using three decisional algorithms.The incidence of DDI-related ADRs during the study period was calculated. Logistic regression analysis was used to study DDI-related ADR predictors. Results: A total of 433 patients completed the study. The incidence of DDI-related ADRs was 6.5%. A multivariate analysis indicated that the adjusted odds ratios (ORs) rose from 0.91 (95% confidence interval [CI] = 0.75-1.12, p = 0.06) in patients aged 65-69 years to 4.40 (95% CI = 3.00-6.12, p < 0.01) in patients aged 80 years or older. Patients who presented two to three diagnosed diseases presented lower adjusted ORs (OR = 0.93 [95% CI = 0.68-1.18, p = 0.08]) than patients who presented six or more diseases (OR = 1.12 [95% CI = 1.02-2.01, p < 0.01]). Elderly patients who took five or more drugs had a significantly higher risk of DDI-related ADRs (OR = 2.72 [95% CI = 1.92-3.12, p < 0.01]) than patients who took three to four drugs (OR = 0.93 [95% CI = 0.74-1.11, p = 0.06]). No significant difference was found with regard to sex (OR = 1.08 [95% CI 0.48-2.02, p = 0.44]). Conclusion: The incidence of DDI-related ADRs in elderly outpatients was significant, and most of the events presented important clinical consequences. Because clinicians still have difficulty managing this problem, highlighting the factors that increase the risk of DDI-related ADRs is essential. Polypharmacy was found to be a significant predictor of DDI-related ADRs in our sample.pt_BR
dc.description.localAlbertapt_BR
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