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https://ri.ufs.br/jspui/handle/riufs/23559| Document Type: | Artigo |
| Title: | Sesquiterpenos produzidos pelo fungo endofítico Phomopsis cassiae com atividade antifúngica e inibidora de acetilcolinesterase |
| Other Titles: | Sesquiterpenes produced by endophytic fungus Phomopsis cassiae with antifungal and acetylcholinesterase inhibition activities |
| Authors: | Zanardi, Lisinéia Maria Bolzani, Vanderlan da Silva Cavalheiro, Alberto José Silva, Dulce Helena Siqueira Trevisan, Henrique Celso Araujo, Angela Regina Silva, Geraldo Humberto Teles, Helder Lopes Young, Maria Claudia Marx |
| Issue Date: | 2012 |
| Resumo : | O estudo químico do extrato bruto AcOEt produzido pelo fungo endofítico P. cassiae resultou no isolamento de quatro sesquiterpenos da classe dos cadinanos, sendo dois novos estereoisômeros Rel. (7R,9S,10R)-3,9-di-hidroxicalameneno (1) e Rel. (7R,9R,10R)- 3,9-di-hidroxicalameneno (2) e os conhecidos Rel. (7S,10R)-3- hidroxicalamen-8-ona (3) e aristelegona-A (4). As estruturas das substâncias foram determinadas ou elucidadas pela análise dos espectros de infravermelho, EM, RMN de 1 H e 13C, uni e bidimensionais. As substâncias 1-4 foram avaliadas quanto ao potencial antifúngico e inibidor de acetilcolinesterase. |
| Abstract: | Two new diastereoisomeric cadinanes sesquiterpenes 3,9-dihydroxycalamenene (1-2), along with the known 3-hydroxycalamen-8-one (3) and aristelegone-A (4), were isolated from ethyl acetate extract of Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures, including relative stereochemistry, were determined on the basis of detailed interpretation of 2D NMR spectra and comparison with related known compounds. Compounds 1-4 displayed antifungal activity against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as inhibition of acetylcholinesterase. |
| Keywords: | Phomopsis cassiae Fungo endofítico Sesquiterpenos Endophytic fungus Sesquiterpenes |
| ISSN: | 1678-7064 |
| Is part of: | Química Nova |
| Language: | por |
| Publisher / Institution : | Sociedade Brasileira de Química |
| Citation: | ZANARDI, L. M. et al. Sesquiterpenos produzidos pelo fungo endofítico Phomopsis cassiae com atividade antifúngica e inibidora de acetilcolinesterase. Química Nova, Campinas, v. 35, n. 11, p. 2233-2236, 2012. Disponível em: https://www.scielo.br/j/qn/a/pJG4d8y57z93wQLFQ53PXVL/?lang=pt. Acesso em: 17 out. 2025 |
| License: | Creative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0) |
| URI: | https://ri.ufs.br/jspui/handle/riufs/23559 |
| Appears in Collections: | DQI - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| SesquiterpenosProduzidosFungoEndofitico.pdf | 1,17 MB | Adobe PDF |  View/Open |
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