Uso preemptivo do cicladol na sensibilidade causada pelo clareamento dental em consultório: ensaio clínico randomizado, triplo cego, cross-over, placebo-controlado

Abstract

In-office tooth bleaching with hydrogen peroxide use in high concentration, despite it is a conservative technique showing excelent results, often it leads to postoperative tooth sensitivity and this is the main adverse effect related to whitening which can cause abandonment of treatment by pacients. The purpose of this study was to evaluate the effect of the preemptive use of the non-steroidal anti-inflammatory Cicladol in a single dose of 30 minutes prior to the office bleaching in the prevention of the dental sensitivity reported by the patients. Fifty patients underwent 2 dental bleaching sessions with 35% hydrogen peroxide used in a single application of 45 minutes in 2 sessions, with an interval of 7 days. Thirty minutes before the procedure, the patient randomly received a single dose of Cicladol (200 mg) or placebo in a triple-blind, randomized crossover design. The level of sensitivity was assessed using the verbal and visual analogue scales (EVA) immediately after removal of the bleaching agent; and after 24 hours of the procedure, the patients recorded the maximum level of perceived dental sensitivity during the first 24 hours and the level of sensitivity at that time. The bleaching efficacy of the procedures was assessed using the Bleach Guide. The relative risk of sensitivity was calculated and adjusted by session, while the overall risk comparison was performed by the McNemar test. The verbal scale data were analyzed for the level of tooth sensitivity by the Mann-Whitney test. For EVA, the data were submitted to the T test to compare the treatments at each evaluation time. Data on the sensitivity level for both scales and color were submitted to the Wilcoxon and Mann-Whitney tests (α = 0.05). Results showed that pre-emptive administration of Cicladol did not affect the risk and level of tooth sensitivity when compared to placebo, regardless of the time of evaluation. The treatment sequence did not affect the efficacy of claremento. It was concluded that the preventive administration of a single dose of Cicladol prior to dental office whitening was unable to significantly reduce risk and level of sensitivity.