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Por favor, use este identificador para citar o enlazar este ítem: https://ri.ufs.br/jspui/handle/riufs/24644
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dc.contributor.authorAires, Marlúcia Bastos-
dc.contributor.authorSantos, José Ronaldo Alves dos-
dc.contributor.authorSouza, Karine dos Santos-
dc.contributor.authorFarias, Priscilla Silva-
dc.contributor.authorSantos, Anne Carolline Veríssimo dos-
dc.contributor.authorFioretto, Emerson Ticona-
dc.contributor.authorMaria, Durvanei Augusto-
dc.date.accessioned2026-02-25T19:12:15Z-
dc.date.available2026-02-25T19:12:15Z-
dc.date.issued2015-
dc.identifier.citationAIRES, M. B. et al. Rat visceral yolk sac cells: viability and expression of cell markers during maternal diabetes. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 48, n. 8, p. 676–682, 2015. Disponível em: https://www.scielo.br/j/bjmbr/a/ChQVGPQVP5r6LyYSkJNbVyq/?lang=en. Acesso em: 25 fev. 2026.pt_BR
dc.identifier.issn1414-431X-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/24644-
dc.languageengpt_BR
dc.publisherAssociação Brasileira de Divulgação Científicapt_BR
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchpt_BR
dc.subjectVisceral yolk saceng
dc.subjectDiabeteseng
dc.subjectEmbryoeng
dc.subjectPregnancyeng
dc.subjectCell markerseng
dc.titleRat visceral yolk sac cells: viability and expression of cell markers during maternal diabetespt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoThe function of the visceral yolk sac (VYS) is critical for embryo organogenesis until final fetal development in rats, and can be affected by conditions such as diabetes. In view of the importance of diabetes during pregnancy for maternal and neonatal health, the objective of this study was to assess fetal weight, VYS cell markers, and viability in female Wistar rats (200–250 g) with induced diabetes (alloxan, 37 mg/kg) on the 8th gestational day (gd 8). At gd 15, rats from control (n=5) and diabetic (n=5) groups were anesthetized and laparotomized to remove the uterine horns for weighing of fetuses and collecting the VYS. Flow cytometry was used for characterizing VYS cells, and for determining mitochondrial activity, cell proliferation, DNA ploidy, cell cycle phases, and caspase-3 activity. Fetal weight was reduced in the diabetic group. Expression of the cell markers CD34, VEGFR1, CD115, CD117, CD14, CCR2, CD90, CD44, STRO-1, OCT3/4, and Nanog was detected in VYS cells in both groups. In the diabetic group, significantly decreased expression of CD34 (Po0.05), CCR2 (Po0.001), and OCT3/4 (Po0.01), and significantly increased expression of CD90 (Po0.05), CD117 (Po0.01), and CD14 (Po0.05) were observed. VYS cells with inactive mitochondria, activated caspase-3, and low proliferation were present in the rats with diabetes. Severe hyperglycemia caused by maternal diabetes had negative effects on pregnancy, VYS cell viability, and the expression of cell markers.pt_BR
dc.description.localRibeirão Pretopt_BR
dc.identifier.doihttps://doi.org/10.1590/1414-431X20154739-
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DMO - Artigos de periódicos

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