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2. PRODUÇÃO CIENTÍFICA
3. DOL - Departamento de Odontologia (Lagarto)
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Tipo de Documento:	Artigo
Título:	Different contribution of BRINP3 gene in chronic periodontitis and peri-implantitis: a crosssectional study
Autor(es):	Casado, Priscila Ladeira Aguiar, Diego P. Costa, Lucas C. Fonseca, Marcos A. Vieira, Thays C. S. Alvim-Pereira, Claudia Cristina Alvim-Pereira, Fabiano Deeley, Kathleen Granjeiro, José Mauro Trevilatto, Paula Cristina Vieira, Alexandre R.
Data do documento:	2015
Resumo:	Background: Peri-implantitis is a chronic inflammation, resulting in loss of supporting bone around implants. Chronic periodontitis is a risk indicator for implant failure. Both diseases have a common etiology regarding inflammatory destructive response. BRINP3 gene is associated with aggressive periodontitis. However, is still unclear if chronic periodontitis and peri-implantitis have the same genetic background. The aim of this work was to investigate the association between BRINP3 genetic variation (rs1342913 and rs1935881) and expression and susceptibility to both diseases. Methods: Periodontal and peri-implant examinations were performed in 215 subjects, divided into: healthy (without chronic periodontitis and peri-implantitis, n = 93); diseased (with chronic periodontitis and peri-implantitis, n = 52); chronic periodontitis only (n = 36), and peri-implantitis only (n = 34). A replication sample of 92 subjects who lost implants and 185 subjects successfully treated with implants were tested. DNA was extracted from buccal cells. Two genetic markers of BRINP3 (rs1342913 and rs1935881) were genotyped using TaqMan chemistry. Chi-square (p < 0.05) compared genotype and allele frequency between groups. A subset of subjects (n = 31) had gingival biopsies harvested. The BRINP3 mRNA levels were studied by CT method (2ΔΔCT). Mann–Whitney test correlated the levels of BRINP3 in each group (p < 0.05). Results: Statistically significant association between BRINP3 rs1342913 and peri-implantitis was found in both studied groups (p = 0.04). The levels of BRINP3 mRNA were significantly higher in diseased subjects compared to healthy individuals (p = 0.01). Conclusion: This study provides evidence that the BRINP3 polymorphic variant rs1342913 and low level of BRINP3 expression are associated with peri-implantitis, independently from the presence of chronic periodontitis.
Palavras-chave:	Chronic periodontitis Peri-implantitis Genetic polymorphism Gene expression
ISSN:	1472-6831
Parte de :	BMC Oral Health
Idioma:	eng
Instituição/Editora:	BioMed Central
Citação:	CASADO, P. L. et al. Different contribution of BRINP3 gene in chronic periodontitis and peri-implantitis: a crosssectional study. BMC Oral Health, London, v. 15, n. 33, 2015. Disponível em: https://link.springer.com/article/10.1186/s12903-015-0018-6. Acesso em: 9 mar. 2026.
Licença:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identificador:	https://doi.org/10.1186/s12903-015-0018-6
URI:	https://ri.ufs.br/jspui/handle/riufs/24715
Aparece nas coleções:	DOL - Artigos de periódicos

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