Cistite Hemorrágica Estéril em cão devido ao uso do quimioterápico ciclofosfamida : relato de caso

Abstract

This Undergraduate Thesis describes the activities developed during the Mandatory Supervised Internship in Small Animal Internal Medicine and Surgery, conducted at the Pet&Zoo+ Veterinary Clinic in Aracaju - SE, totaling 456 hours. The report details the facility's infrastructure and the clinical cases followed, consisting of 87 consultations, in which dermatological disorders and diseases of the urinary and renal systems were the most prevalent. A case report is presented of a mixed-breed (MB) canine patient diagnosed with Sterile Hemorrhagic Cystitis (SHC) resulting from the use of the chemotherapeutic agent cyclophosphamide. The literature review addresses the pathophysiology of urothelial injury mediated by the metabolite acrolein, which induces oxidative stress and severe inflammation in the urinary bladder. The clinical case discusses the diagnostic challenges and therapeutic strategies employed, such as intensive fluid therapy and the use of the uroprotective drug mesna.