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https://ri.ufs.br/jspui/handle/riufs/25129| Tipo de Documento: | Artigo |
| Título: | Preparation, characterization, and pharmacological activity of Cymbopogon winterianus jowitt ex Bor (Poaceae) leaf essential oil of b-Cyclodextrin inclusion complexes |
| Autor(es): | Santos, Priscila L. Araújo, Adriano Antunes de Souza Quintans, Jullyana de Souza Siqueira Oliveira, Makson Gleydson Brito de Brito, Renan Guedes de Serafini, Mairim Russo Menezes, Paula dos Passos Santos, Márcio Roberto Viana dos Alves, Pericles Barreto Lucca Júnior, Waldecy de Blank, Arie Fitzgerald Rocca, Viviana La Almeida, Reinaldo Nobrega de Quintans Júnior, Lucindo José |
| Data do documento: | 2015 |
| Resumo: | This study aimed to evaluate the orofacial antinociceptive effect of the Cymbopogon winterianus essential oil (LEO) complexed in b-cyclodextrin (LEO-CD) and to assess the possible involvement of the central nervous system (CNS). The LEO was extracted, chromatographed, and complexed in b-cyclodextrin. The complex was characterized by differential scanning calorimetry (DSC)and thermogravimetry derivative (TG/DTG). Male Swiss mice (2-3 months) were treated with LEO-CD (50–200 mg/kg, p.o.),vehicle (distilled water, p.o.), or standard drug (i.p.) and subjected to the orofacial nociception formalin-, capsaicin-, and glutamate-induced. After the formalin test, the animals were perfused and the brains subjected to immunofluorescence for Fos. The rota-rodtest (7 rpm/min) was carried out. Geraniol (37.57%) was the main compound of LEO. DSC and TG/DTG proved the complexation.The orofacial nociceptive behavior was significantly (p < 0.05) reduced. The number of Fos-positive cells was significantly changedin the dorsal raphe nucleus (p < 0.01), locus coeruleus (p < 0.001), trigeminal nucleus (p < 0.05), and trigeminal thalamic tract (p < 0.05). LEO-CD did not cause changes in motor coordination in the rota-rod test. Thus, our results suggested that LEO-CDhas an orofacial antinociceptive profile, probably mediated by the activation of the CNS without changing the motor coordination. |
| Palavras-chave: | Antinociceptive effect Cymbopogon winterianus essential oil Central nervous system |
| ISSN: | 1741-4288 |
| Parte de : | Evidence-Based Complementary and Alternative Medicine |
| Idioma: | eng |
| Instituição/Editora: | Hindawi Publishing Corporation |
| Citação: | SANTOS, P. L. et al. Preparation, characterization, and pharmacological activity of Cymbopogon winterianus jowitt ex Bor (Poaceae) leaf essential oil of b-Cyclodextrin inclusion complexes. Evidence-Based Complementary and Alternative Medicine, New York, n. 1, 2015. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2015/502454. Acesso em: 4 maio 2026. |
| Licença: | Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0) |
| Identificador: | https://doi.org/10.1155%2F2015%2F502454 |
| URI: | https://ri.ufs.br/jspui/handle/riufs/25129 |
| Aparece nas coleções: | PPGCS - Artigos de periódicos |
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| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| PreparationPharmacologicalActivityCymbopogonWinterianus.pdf | 4,86 MB | Adobe PDF |  Visualizar/Abrir |
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