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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25220
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dc.contributor.authorOliveira, Valter Oberdan Borges de-
dc.contributor.authorOliveira, Juliana Passos Rocha-
dc.contributor.authorFrança, Eloy Vianey Carvalho de-
dc.contributor.authorBrito, Hugo Leite de Farias-
dc.contributor.authorNascimento, Tereza Virgínia-
dc.contributor.authorFrança, Alex-
dc.date.accessioned2026-07-06T19:16:27Z-
dc.date.available2026-07-06T19:16:27Z-
dc.date.issued2016-
dc.identifier.citationOLIVEIRA, V. O. B. et al. Advanced liver injury in patients with chronic hepatitis B and viral load below 2,000 IU/mL. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 58, n. 65, 2016. Disponível em: https://www.scielo.br/j/rimtsp/a/5XffsMjBWKstmpHHYLgQb6N/?lang=en. Acesso em: 15 jun. 2026.pt_BR
dc.identifier.issn1678-9946-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25220-
dc.languageengpt_BR
dc.publisherInstituto de Medicina Tropical de São Paulopt_BR
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulopt_BR
dc.subjectHepatitis Beng
dc.subjectViral loadeng
dc.subjectLiver injuryeng
dc.titleAdvanced liver injury in patients with chronic hepatitis B and viral load below 2,000 IU/mLpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0)pt_BR
dc.description.resumoIntroduction: According to the guidelines, the viral load of 2,000 IU/mL is considered the level to differentiate between inactive carriers and HBeAg(-) chronic hepatitis B patients. Even so, liver damage may be present in patients with lower viral load levels, mainly related to regional variations. This study aims to verify the presence of liver injury in patients with viral load below 2,000 IU/ mL. Methods: Patients presenting HBsAg(+) for more than six months, Anti-HBe(+)/HBeAg(-), viral load below 2,000 IU/mL and serum ALT levels less than twice the upper limit of normality underwent liver biopsy. Clinical and laboratory characteristics were evaluated in relation to the degree of histologic alteration. Liver injury was considered advanced when F ≥ 2 and/or A ≥ 2 by the METAVIR classification. Results: 11/27 (40.7%) patients had advanced liver injury, with a mean viral load of 701.0 (± 653.7) IU/ mL versus 482.8 (± 580.0) IU/mL in patients with mild injury. The comparison between the mean values of the two groups did not find a statistical difference (p = 0.37). The average of serum aminotransferases was not able to differentiate light liver injury from advanced injury. Conclusions: In this study, one evaluation of viral load did not exclude the presence of advanced liver damage. Pathologic assessment is an important tool to diagnose advanced liver damage and should be performed in patients with a low viral load to indicate early antiviral treatment.pt_BR
dc.description.localSão Paulopt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/S1678-9946201658065-
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