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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25242
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dc.contributor.authorFigueiredo, Thais Pandini-
dc.contributor.authorLucas, Rosymar Coutinho de-
dc.contributor.authorCazzaniga, Rodrigo Anselmo-
dc.contributor.authorFrança, Carolina Nunes-
dc.contributor.authorSegato, Fernando-
dc.contributor.authorTaglialegna, Rafael-
dc.contributor.authorMaffei, Claudia Maria Leite-
dc.date.accessioned2026-07-06T19:21:33Z-
dc.date.available2026-07-06T19:21:33Z-
dc.date.issued2016-
dc.identifier.citationFIGUEIREDO, T. P. et al. Antifungal susceptibility testing and genotyping characterization of Cryptococcus neoformans and gattii isolates from HIV-infected patients of Ribeirão Preto, São Paulo, brazil. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 58, n. 69, 2016. Disponível em: https://www.scielo.br/j/rimtsp/a/58DxCc3CMmmdfBGVGSdxWgM/?lang=en. Acesso em: 2 jul. 2026.pt_BR
dc.identifier.issn1678-9946-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25242-
dc.languageengpt_BR
dc.publisherInstituto de Medicina Tropical de São Paulopt_BR
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulopt_BR
dc.subjectCryptococcus neoformanseng
dc.subjectSerotypingeng
dc.subjectGenotypingeng
dc.subjectFingerprintingeng
dc.subjectAntifungal agentseng
dc.subjectMating typeeng
dc.subjectHIV-patientseng
dc.titleAntifungal susceptibility testing and genotyping characterization of Cryptococcus neoformans and gattii isolates from HIV-infected patients of Ribeirão Preto, São Paulo, brazilpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0)pt_BR
dc.description.resumoCryptococcosis is a leading invasive fungal infection in immunocompromised patients. Considering the high prevalence and severity of these infections in immunocompromised patients attended at HC-FMRP-USP, the present research aimed to characterize the clinical isolates of Cryptococcus strains by biochemical and molecular methods and evaluate antifungal susceptibility of clinical isolates. Fifty isolates from 32 HIV-positive patients were obtained at HC-FMRP-USP. Most of the isolates (78.1%) were identified as C. neoformans, and 100% of C. neoformans and C. gattii strains were susceptible to amphotericin B, ketoconazole and fluconazole. All isolates were classified as serotype A (grubbii variety) by PCR and most of them were characterized in mating type MATα. PCR analysis of specific M13 microsatellite sequence revealed that VNI type was predominant among C. neoformans, while VGII was predominant among C. gattii. The strains did not show a significant resistance to the antifungals tested, and Canavanine-Glycine-Bromthymol Blue Agar (CGB) proved to be a reliable test presenting a good correlation with the molecular characterization. C. neoformans isolated from disseminated infections in the same patient showed molecular identity when different anatomical sites were compared; besides, the studied strains did not present a significant increase in resistance to antifungal agents. In addition, the homogeneity of the molecular types and detection of the mating types suggested a low possibility of crossing among the strains.pt_BR
dc.description.localSão Paulopt_BR
dc.identifier.doihttps://doi.org/10.1590/S1678-9946201658069-
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