1. Repositório Institucional da Universidade Federal de Sergipe - RI/UFS
  2. PRODUÇÃO CIENTÍFICA
  3. DMO - Departamento de Morfologia
  4. DMO - Artigos de periódicos
Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25535
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorMartins, Waleska Barros-
dc.contributor.authorRodrigues, Sheyla Alves-
dc.contributor.authorSilva, Hatamy K.-
dc.contributor.authorDantas, Camila Gomes-
dc.contributor.authorLucca Júnior, Waldecy de-
dc.contributor.authorXavier Filho, Lauro-
dc.contributor.authorCardoso, Juliana Cordeiro-
dc.contributor.authorGomes, Margarete Zanardo-
dc.date.accessioned2026-07-14T17:46:19Z-
dc.date.available2026-07-14T17:46:19Z-
dc.date.issued2016-
dc.identifier.citationMARTINS, W. B. et al. Neuroprotective effect of Portulaca oleracea extracts against 6-hydroxydopamine-induced lesion of dopaminergic neurons. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 88, n. 3, p. 1439–1450, 2016. Disponível em: https://www.scielo.br/j/aabc/a/qQJq6Lj8KFthph8xSDfDQ5L/?lang=en. Acesso em: 14 jul. 2026.pt_BR
dc.identifier.issn1678-2690-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25535-
dc.languageengpt_BR
dc.publisherAcademia Brasileira de Ciênciaspt_BR
dc.relation.ispartofAnais da Academia Brasileira de Ciênciaspt_BR
dc.subjectParkinson diseaseeng
dc.subjectAntioxidant response elementseng
dc.subjectLevodopaeng
dc.subjectPurslaneeng
dc.titleNeuroprotective effect of Portulaca oleracea extracts against 6-hydroxydopamine-induced lesion of dopaminergic neuronspt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoThe Portulaca oleracea L. (Portulacaceae) is a cosmopolitan species with a wide range of biological activities, including antioxidant and neuroprotective actions. We investigated the effects of P. oleracea extracts in a 6-hydroxydopamine rat model of Parkinson’s disease, a debilitating disorder without effective treatments. Chemical profiles of aqueous and ethanolic extracts of whole plant were analyzed by thin layer chromatography and the antioxidant activity was assessed by 2,2-diphenyl-1-picrilhidrazila method. Male Wistar rats received intrastriatal 6-hydroxydopamine and were treated with vehicle or extracts (oral, 200 and 400 mg/kg) daily for two weeks. The behavioral open field test was conducted at days 1 and 15. Immunohistochemical analysis was performed 4 weeks after surgery to quantify tyrosine-hydroxylase cell counts in the substantia nigra pars compacta. Extracts presented antioxidant activity in concentrations above 300 µg/kg. The chromatographic analysis revealed the presence of Levodopa, alkaloids, flavonoids, saponins, tannins, terpenoids and polysaccharides. Both extracts improved motor recovery 15 days after lesion and protected from tyrosine-hydroxylase cell loss after 4 weeks, but these effects were more evident for the aqueous extract. Because the dopamine precursor is present, in addition to antioxidant compounds and neuroprotective effects, P. oleracea can be considered as potential strategy for treating Parkinson’s disease.pt_BR
dc.description.localRio de Janeiropt_BR
dc.identifier.doihttps://doi.org/10.1590/0001-3765201620150574-
Aparece nas coleções:DMO - Artigos de periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
NeuroprotectiveEffectPortulacaOleraceaExtracts.pdf2,06 MBAdobe PDFThumbnail
Visualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.