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Please use this identifier to cite or link to this item: https://ri.ufs.br/jspui/handle/riufs/25642
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dc.contributor.authorStreck, Letícia-
dc.contributor.authorSarmento, Victor Hugo Vitorino-
dc.contributor.authorMachado, Paula Renata Lima-
dc.contributor.authorFarias, Kleber Juvenal Silva-
dc.contributor.authorPedrosa, Matheus de Freitas Fernandes-
dc.contributor.authorSilva Junior, Arnobio Antonio da-
dc.date.accessioned2026-07-23T18:03:58Z-
dc.date.available2026-07-23T18:03:58Z-
dc.date.issued2016-
dc.identifier.citationSTRECK, L. et al. Phase transitions of isotropic to anisotropic biocompatible lipid-based drug delivery systems overcoming insoluble benznidazole loading. International Journal of Molecular Sciences, Basel, v. 17, n. 7, 2016. Disponível em: https://www.mdpi.com/1422-0067/17/7/981. Acesso em: 23 jul. 2026.pt_BR
dc.identifier.issn1422-0067-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25642-
dc.languageengpt_BR
dc.publisherMDPI Centerpt_BR
dc.relation.ispartofInternational Journal of Molecular Sciencespt_BR
dc.subjectNanoemulsionseng
dc.subjectLiquid crystalseng
dc.subjectBiocompatible colloidal carrierseng
dc.subjectRheologyeng
dc.subjectLipid-based drug delivery systemseng
dc.subjectBenznidazoleeng
dc.titlePhase transitions of isotropic to anisotropic biocompatible lipid-based drug delivery systems overcoming insoluble benznidazole loadingpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoPrevious studies reported low benznidazole (BNZ) loading in conventional emulsions due to the weak interaction of the drug with the most common oils used to produce foods or pharmaceuticals. In this study, we focused on how the type of surfactant, surfactant-to-oil ratio w/w (SOR) and oil-to-water ratio w/w (OWR) change the phase behavior of different lipid-based drug delivery systems (LBDDS) produced by emulsion phase inversion. The surfactant mixture composed of soy phosphatidylcholine and sodium oleate (1:7, w/w, hydrophilic lipophilic balance = 16) stabilized medium chain triglyceride in water. Ten formulations with the clear aspect or less turbid dispersions (five with the SOR ranging from 0.5 to 2.5 and five with the OWR from 0.06 to 0.4) were selected from the phase behavior diagram to assess structural features and drug-loading capacity. The rise in the SOR induced the formation of distinct lipid-based drug delivery systems (nanoemulsions and liquid crystal lamellar type) that were identified using rheological measurements and cross-polarized light microscopy images. Clear dispersions of small and narrow droplet-sized liquid-like nanoemulsions, Newtonian flow-type, were produced at SOR from 0.5 to 1.5 and OWR from 0.12 to 0.4, while clear liquid or gel-like liquid crystals were produced at SOR from 1.5 to 2.5. The BNZ loading was improved according to the composition and type of LBDDS produced, suggesting possible drug location among surfactant layers. The cell viability assays proved the biocompatibility for all of the prepared nanoemulsions at SOR less than 1.5 and liquid crystals at SOR less than 2.5, demonstrating their promising features for the oral or parenteral colloidal delivery systems containing benznidazole for Chagas disease treatment.pt_BR
dc.description.localBaselpt_BR
dc.identifier.doihttps://doi.org/10.3390/ijms17070981-
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