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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25668
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dc.contributor.authorAlcantara-Neves, Neuza Maria-
dc.contributor.authorVeiga, Rafael Valente-
dc.contributor.authorPonte, João Carlos Marques-
dc.contributor.authorCunha, Sérgio Souza da-
dc.contributor.authorSimões, Silvia de Magalhães-
dc.contributor.authorCruz Filho, Álvaro Augusto Souza da-
dc.contributor.authorYazdanbakhsh, Maria-
dc.contributor.authorMatos, Sheila Maria Alvim de-
dc.contributor.authorSilva, Thiago Magalhães-
dc.contributor.authorFigueirêdo, Camila Alexandrina Viana de-
dc.contributor.authorPontes-de-Carvalho, Lain Carlos-
dc.contributor.authorRodrigues, Laura C.-
dc.contributor.authorFiaccone, Rosemeire Leovigildo-
dc.contributor.authorCooper, Philip J.-
dc.contributor.authorBarreto, Mauricio Lima-
dc.date.accessioned2026-07-24T19:48:39Z-
dc.date.available2026-07-24T19:48:39Z-
dc.date.issued2017-
dc.identifier.citationALCANTARA-NEVES, N. M. et al. Dissociation between skin test reactivity and anti-aeroallergen IgE: determinants among urban Brazilian children. PloS One, San Francisco, v. 12, n. 3, 2016. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174089. Acesso em: 24 jul. 2026.pt_BR
dc.identifier.issn1932-6203-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25668-
dc.languageengpt_BR
dc.publisherPublic Library of Sciencept_BR
dc.relation.ispartofPloS Onept_BR
dc.subjectIgEeng
dc.subjectSkin prick testeng
dc.subjectAeroallergenseng
dc.subjectAllergic diseaseseng
dc.titleDissociation between skin test reactivity and anti-aeroallergen IgE: determinants among urban Brazilian childrenpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoBackground: The dissociation between specific IgE and skin prick test reactivity to aeroallergens, a common finding in populations living in low and middle-income countries, has important implications for the diagnosis and treatment of allergic diseases. Few studies have investigated the determinants of this dissociation. In the present study, we explored potential factors explaining this dissociation in children living in an urban area of Northeast Brazil, focusing in particular on factors associated with poor hygiene. Methods: Of 1445 children from low income communities, investigated for risk factors of allergies, we studied 481 with specific IgE antibodies to any of Blomia tropicalis, Dermatophagoides pteronyssinus, Periplaneta americana and Blatella germanica allergens. Data on demographic, environmental and social exposures were collected by questionnaire; serum IgG and stool examinations were done to detect current or past infections with viral, bacterial, protozoan and intestinal helminth pathogens. We measured atopy by skin prick testing (SPT) and specific IgE (sIgE) to aerollergens in serum (by ImmunoCAP). SIgE reactivity to B. tropicalis extract depleted of carbohydrates was measured by an in-house ELISA. Total IgE was measured by in house capture ELISA. SNPs were typed using Illumina Omni 2.5. Results Negative skin prick tests in the presence of specific IgE antibodies were frequent. Factors independently associated with a reduced frequency of positive skin prick tests were large number of siblings, the presence of IgG to herpes simplex virus, Ascaris lumbricoides and Trichuris trichiura infections, living in neighborhoods with infrequent garbage collection, presence of rodents and cats in the household and sIgE reactivity to glycosylated B. tropicalis allergens. Also, SNP on IGHE (rs61737468) was negatively associated with SPT reactivity. Conclusions: A variety of factors were found to be associated with decreased frequency of SPT such as unhygienic living conditions, infections, total IgE, IgE response to glycosylated allergens and genetic polymorphisms, indicating that multiple mechanisms may be involved. Our data, showing that exposures to an unhygienic environment and childhood infections modulate immediate allergen skin test reactivity, provide support for the “hygiene hypothesis”.pt_BR
dc.description.localSan Franciscopt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0174089-
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