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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25900
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dc.contributor.authorBomfim, Lays Gisele Santos-
dc.contributor.authorMagalhães, Lucas Sousa-
dc.contributor.authorSantos Filho, Marcello Augusto Anchieta-
dc.contributor.authorPeres, Nalu Teixeira de Aguiar-
dc.contributor.authorCorrêa, Cristiane Bani-
dc.contributor.authorTanajura, Diego Moura-
dc.contributor.authorSilva, Angela M.-
dc.contributor.authorLipscomb, Michael W.-
dc.contributor.authorBorges, Valéria de Matos-
dc.contributor.authorJesus, Amélia Maria Ribeiro de-
dc.contributor.authorAlmeida, Roque Pacheco de-
dc.contributor.authorMoura, Tatiana Rodrigues de-
dc.date.accessioned2026-08-26T19:23:05Z-
dc.date.available2026-08-26T19:23:05Z-
dc.date.issued2017-11-
dc.identifier.citationBOMFIM, L. G. S. et al. Leishmania infantum Induces the release of sTREM-1 in visceral leishmaniasis. Frontiers in Microbiology, Lausanne, v. 8, n. 2265, nov. 2017. DOI: https://doi.org/10.3389/fmicb.2017.02265. Disponível em: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.02265/full. Acesso em: 26 ago. 2026.pt_BR
dc.identifier.issn1664-302X-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25900-
dc.languageengpt_BR
dc.publisherFrontiers Media S. A.pt_BR
dc.relation.ispartofFrontiers in Microbiologypt_BR
dc.subjectVisceral leishmaniasiseng
dc.subjectLeishmania infantumeng
dc.subjectNeutrophilseng
dc.subjectSTREM-1eng
dc.subjectTREM-1eng
dc.titleLeishmania infantum Induces the release of sTREM-1 in visceral leishmaniasispt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoVisceral leishmaniasis (VL) is a systemic transmissible disease that remains to be a major global health problem. The inflammatory response during VL is characterized by the release of several cytokines and other pro-inflammatory mediators. Triggering Receptor Expressed on Myeloid Cells (TREM) are a group of evolutionarily conserved membrane-bound surface receptors expressed on neutrophils and monocytes. Engagement of TREM-1 directs intracellular signaling events that drive cytokine production, degranulation, and phagocytosis. In certain inflammatory-associated diseases, TREM-1 can also be found as a soluble form (sTREM-1), which can negatively regulate TREM-1 receptor signaling. In these studies, we now find that high levels of circulating sTREM-1 correlate directly with VL disease severity. In particular, high levels of sTREM-1 were observed in non-survivor VL patients. Furthermore, these levels of sTREM-1 positively correlated with liver size and negatively correlated with leukocyte counts and hemoglobin concentration. Moreover, we found that neutrophils exposure in vitro to Leishmania infantum modulates TREM-1, DAP12, and IL-8 gene expression, while also increasing release of sTREM-1. Finally, results revealed that higher sTREM-1 levels are associated with increasing parasite ratio. Taken together, these studies suggest that L. infantum may modulate TREM-1 in neutrophils and high levels of this molecule is associated with severe VL.pt_BR
dc.description.localLausannept_BR
dc.identifier.doihttps://doi.org/10.3389/fmicb.2017.02265-
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