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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25923
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dc.contributor.authorBezerra, Clarissa Loureiro Campêlo-
dc.contributor.authorCagni, Fernanda Carvalho-
dc.contributor.authorFigueredo, Diego de Siqueira-
dc.contributor.authorOliveira Júnior, Luiz Gonzaga de-
dc.contributor.authorSilva Neto, Antonio Braz da-
dc.contributor.authorMacêdo, Priscila Tavares-
dc.contributor.authorSantos, José Ronaldo dos-
dc.contributor.authorIzídio, Geison de Souza-
dc.contributor.authorRibeiro, Alessandra Mussi-
dc.contributor.authorAndrade, Tiago Gomes de-
dc.contributor.authorGodeiro Júnior, Clécio de Oliveira-
dc.contributor.authorSilva, Regina Helena da-
dc.date.accessioned2026-08-27T19:24:09Z-
dc.date.available2026-08-27T19:24:09Z-
dc.date.issued2017-06-
dc.identifier.citationBEZERRA, C. L. C. et al. Variants in SNCA gene are associated with Parkinson’s disease risk and cognitive symptoms in a Brazilian sample. Frontiers in Aging Neuroscience, Lausanne, v. 9, n. 198, jun. 2017. DOI: https://doi.org/10.3389/fnagi.2017.00198. Disponível em: https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2017.00198/full. Acesso em: 27 ago. 2026.pt_BR
dc.identifier.issn1663-4365-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25923-
dc.languageengpt_BR
dc.publisherFrontiers Media S. A.pt_BR
dc.relation.ispartofFrontiers in Aging Neurosciencept_BR
dc.subjectParkinson’s diseaseeng
dc.subjectAlpha-synucleineng
dc.subjectSNCA geneeng
dc.subjectPolymorphismeng
dc.subjectCognitive impairmenteng
dc.subjectClinical assessmenteng
dc.subjectBrazileng
dc.titleVariants in SNCA gene are associated with Parkinson’s disease risk and cognitive symptoms in a Brazilian samplept_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoGenetic susceptibility contributes to the etiology of sporadic Parkinson’s Disease (PD) and worldwide studies have found positive associations of polymorphisms in the alphasynuclein gene (SNCA) with the risk for PD. However, little is known about the influence of variants of SNCA in individual traits or phenotypical aspects of PD. Further, there is a lack of studies with Latin-American samples. We evaluated the association between SNCA single nucleotide polymorphisms (single nucleotide polymorphisms, SNPs – rs2583988, rs356219, rs2736990, and rs11931074) and PD risk in a Brazilians sample. In addition, we investigated their potential interactions with environmental factors and specific clinical outcomes (motor and cognitive impairments, depression, and anxiety). A total of 105 PD patients and 101 controls participated in the study. Single locus analysis showed that the risk allele of all SNPs were more frequent in PD patients (p < 0.05), and the associations of SNPs rs2583988, rs356219, and rs2736990 with increased PD risk were confirmed. Further, the G-rs356219 and C-rs2736990 alleles were associated with early onset PD. T-rs2583988, G-rs356219 and C-2736990 alleles were significantly more frequent in PD patients with cognitive impairments than controls in this condition. In addition, in a logistic regression model, we found an association of cognitive impairment with PD, and the practice of cognitive activity and smoking habits had a protective effect. This study shows for the first time an association of SNCA polymorphism and PD in a South-American sample. In addition, we found an interaction between SNP rs356219 and a specific clinical outcome, i.e., the increased risk for cognitive impairment in PD patients.pt_BR
dc.description.localLausannept_BR
dc.identifier.doihttps://doi.org/10.3389/fnagi.2017.00198-
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