1. Repositório Institucional da Universidade Federal de Sergipe - RI/UFS
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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/26115
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dc.contributor.authorOliveira Filho, Alfredo Dias de-
dc.contributor.authorVieira, Antonio Emanuel Soares-
dc.contributor.authorSilva, Roberta Cruz da-
dc.contributor.authorNeves, Sabrina Joany Felizardo-
dc.contributor.authorGama, Thiago Antonio Barros-
dc.contributor.authorLima, Ryane Vieira-
dc.contributor.authorOliveira, Wlisses Ramon-
dc.contributor.authorDias, Júlia Maria de Gonçalves-
dc.date.accessioned2026-09-15T21:21:21Z-
dc.date.available2026-09-15T21:21:21Z-
dc.date.issued2017-
dc.identifier.citationOLIVEIRA FILHO, A. D. et al. Adverse drug reactions in high-risk pregnant women: a prospective study. Saudi Pharmaceutical Journal, Amsterdam, v. 25, n. 7, p. 1073–1077, 2017. DOI: http://dx.doi.org/10.1016/j.jsps.2017.01.005. Disponível em: https://www.sciencedirect.com/science/article/pii/S1319016417300191?via%3Dihub. Acesso em: 15 set. 2026.pt_BR
dc.identifier.issn2213-7475-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/26115-
dc.languageengpt_BR
dc.publisherElsevierpt_BR
dc.relation.ispartofSaudi Pharmaceutical Journalpt_BR
dc.subjectAdverse drug reactionseng
dc.subjectHigh-risk pregnancyeng
dc.subjectPrevalenceeng
dc.subjectMaternal ageeng
dc.subjectMethyldopaeng
dc.subjectFerrous sulfateeng
dc.subjectDrug-drug interactionseng
dc.titleAdverse drug reactions in high-risk pregnant women: a prospective studypt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição-Não Comercial-Sem Derivações 4.0 Internacional (CC BY-NC-ND 4.0)pt_BR
dc.description.resumoBackground: Because pregnant women are often excluded from clinical trials, there is still very limited information about the risk and safety of prescription drugs during pregnancy. Objective: We aimed to determine the prevalence of Adverse Drug Reactions (ADRs) in high-risk pregnant women after hospital admission. A prospective study was carried out in a teaching maternity hospital in Brazil during six months. Causality of ADRs was assessed through the Naranjo Algorithm and Korean Algorithm for ADR Causality Assessment. Severity of ADRs was assessed using Hartwig’s Severity Assessment Scale. Results: The prevalence of ADRs among the 294 inpatients studied was 8.8%. The mean age was 27.14 (±7.5) y.o. Patient’s age was related to the presence of ADRs, while the manifestation of these events was not associated with any adverse pregnancy outcome. 75.9% of the ADRs reported in the study were of mild severity and 24.1% were of moderate severity. No ADR was caused by drug-drug interaction; however, a significant increase in blood pressure was observed in all patients using concurrent methyldopa and ferrous sulfate. Conclusion: Overall, ADRs were not common events among high-risk pregnant women and no adverse pregnancy outcomes following these events were observed.pt_BR
dc.description.localAmsterdampt_BR
dc.identifier.doihttp://dx.doi.org/10.1016/j.jsps.2017.01.005-
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