Uso de naproxeno na redução de sensibilidade relacionada a clareamento dental : ensaio clínico randomizado controlado

Abstract

Despite the successful of tooth bleaching techniques performed in office, high incidence of trans- and post-operative sensitivity has been reported by patients. This is caused by pulp tissue inflammation, while using anti-inflammatories prior to procedure might be able to reduce the sensitivity. Thus, the aim of this study was evaluated, by a controlled, randomized, double-blinded, clinical trial with cross-over design; the effect of using the anti-inflammatory Naproxen prior to bleaching on tooth sensitivity. Fifty patients were submitted to two sessions of in-office tooth bleaching with 35% hydrogen peroxide used in a single application of 45 minutes with an interval of 7 days. One-hour prior of procedure, the patient randomly received a single dose of Naproxen (500 mg) or placebo in a double-blind, randomized, and crossover design. The sensitivity level was evaluated during and immediately after the bleaching using verbal and analogic visual analogue (VAS) scales; and after 24h using only the verbal scale. The bleaching effectiveness of procedures was evaluated with bleach guide scale. Relative risk to sensitivity was calculated and adjusted by session, while comparison of overall risk was performed by McNemar's Test. Data on the sensitivity level for both scales and shade were subjected to Friedman, Wilcoxon and Mann-Whitney tests (α = 0.05). The use of Naproxen only affected the risk and level of tooth sensitivity reported only at the second session, reducing the risk and level. The sequence of treatment did not affect the beaching effectiveness. Preventive use of Naproxen only reduced the tooth sensitivity reported by patients immediately after the second session of bleaching.