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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/7296
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dc.contributor.authorCardoso, Nathalia Nogueira Rodrigues-
dc.contributor.authorAlviano, Celuta Sales-
dc.contributor.authorBlank, Arie Fitzgerald-
dc.contributor.authorRomanos, Maria Teresa Villela-
dc.contributor.authorFonseca, Beatriz Bastos-
dc.contributor.authorRozental, Sonia-
dc.contributor.authorRodrigues, Igor de Almeida-
dc.contributor.authorMoreno, Daniela Sales Alviano-
dc.date.accessioned2018-02-02T16:13:10Z-
dc.date.available2018-02-02T16:13:10Z-
dc.date.issued2016-
dc.identifier.citationCARDOSO, N. N. R. et al. Synergism effect of the essential oil from Ocimum basilicum var. Maria Bonita and its major components with fluconazole and its influence on ergosterol biosynthesis. Evidence-Based Complementary and Alternative Medicine, v. 2016, 2016. Disponível em: <https://www.hindawi.com/journals/ecam/2016/5647182/>. Acesso em: 02 fev. 2018.pt_BR
dc.identifier.issn1741-427X-
dc.identifier.urihttp://ri.ufs.br/jspui/handle/riufs/7296-
dc.languageengpt_BR
dc.publisherHindawi Publishing Corporationpt_BR
dc.relation.ispartofEvidence-Based Complementary and Alternative Medicinept_BR
dc.subjectEssential oilseng
dc.subjectOcimum basilicumeng
dc.subjectErgosterol biosynthesiseng
dc.subjectÓleos essenciaispor
dc.subjectBiossíntese de ergosterolpor
dc.titleSynergism effect of the essential oil from Ocimum basilicum var. Maria Bonita and its major components with fluconazole and its influence on ergosterol biosynthesispt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoThe aim of this study was to evaluate the activity of the EO and its major components of Ocimum basilicum var. Maria Bonita, a genetically improved cultivar, against the fluconazole sensitive and resistant strains of Candida albicans and Cryptococcus neoformans. Geraniol presented better results than the EO, with a low MIC (76 mg/mL against C. neoformans and 152 mg/mL against both Candida strains). The combination of EO, linalool, or geraniol with fluconazole enhanced their antifungal activity, especially against the resistant strain (MIC reduced to 156, 197, and 38 mg/mL, resp.). The ergosterol assay showed that subinhibitory concentrations of the substances were able to reduce the amount of sterol extracted. The substances tested were able to reduce the capsule size which suggests they have an important mechanism of action. Transmission electron microscopy demonstrated cell wall destruction of C. neoformans after treatment with subinhibitory concentrations. In C. albicans ultrastructure alterations such as irregularities in the membrane, presence of vesicles, and cell wall thickening were observed. The biofilm formation was inhibited in both C. albicans strains at MIC and twice MIC. These results provide further support for the use of O. basilicum EO and its major components as a potential source of antifungal agents.pt_BR
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