Please use this identifier to cite or link to this item: https://ri.ufs.br/jspui/handle/riufs/7298
Document Type: Artigo
Title: Cyclodextrin-complexed Ocimum basilicum leaves essential oil increases fos protein expression in the central nervous system and produce an antihyperalgesic effect in animal models for fibromyalgia
Authors: Nascimento, Simone de Souza
Araujo, Adriano Antunes de Souza
Brito, Renan Guedes de
Serafini, Mairim Russo
Menezes, Paula dos Passos
Santana, Josimari Melo de
Lucca Junior, Waldecy de
Alves, Péricles Barreto
Blank, Arie Fitzgerald
Oliveira, Rita de Cássia Menezes
Oliveira, Aldeidia Pereira de
Albuquerque Junior, Ricardo Luiz Cavalcanti de
Almeida, Jackson Roberto Guedes da Silva
Quintans Júnior, Lucindo José
Issue Date: 2015
Resumo : O. basilicum leaves produce essential oils (LEO) rich in monoterpenes. The short half-life and water insolubility are limitations for LEO medical uses. β-Cyclodextrin (β-CD) has been employed to improve the pharmacological properties of LEO. We assessed the antihyperalgesic profile of LEO, isolated or complexed in β-CD (LEO/β-CD), on an animal model for fibromyalgia. Behavioral tests: mice were treated every day with either LEO/β-CD (25, 50 or 100 mg/kg, p.o.), LEO (25 mg/kg, p.o.), tramadol (TRM 4 mg/kg, i.p.) or vehicle (saline), and 60 min after treatment behavioral parameters were assessed. Therefore, mice were evaluated for mechanical hyperalgesia (von Frey), motor coordination (Rota-rod) and muscle strength (Grip Strength Metter) in a mice fibromyalgia model. After 27 days, we evaluated the central nervous system (CNS) pathways involved in the effect induced by experimental drugs through immunofluorescence protocol to Fos protein. The differential scanning analysis (DSC), thermogravimetry/derivate thermogravimetry (TG/DTG) and infrared absorption spectroscopy (FTIR) curves indicated that the products prepared were able to incorporate the LEO efficiently. Oral treatment with LEO or LEO-βCD, at all doses tested, produced a significant reduction of mechanical hyperalgesia and we were able to significantly increase Fos protein expression. Together, our results provide evidence that LEO, isolated or complexed with β-CD, produces analgesic effects on chronic non-inflammatory pain as fibromyalgia.
Keywords: Ocimum basilicum
Essential oils
β-cyclodextrin
Pain
Fos protein
Fibromyalgia
Óleos essenciais
β-ciclodextrina
Fibromialgia
ISSN: 1422-0067
Is part of: International Journal of Molecular Sciences
Language: eng
Publisher / Institution : MDPI AG
Citation: NASCIMENTO, S. de S. et al. Cyclodextrin-complexed Ocimum basilicum leaves essential oil increases fos protein expression in the central nervous system and produce an antihyperalgesic effect in animal models for fibromyalgia. International Journal of Molecular Sciences, Basel, v. 16, n. 1, p. 547-563, jan. 2015. Disponível em: <http://www.mdpi.com/1422-0067/16/1/547>. Acesso em: 02 fev. 2018.
License: Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
URI: http://ri.ufs.br/jspui/handle/riufs/7298
Appears in Collections:DEA - Artigos de periódicos

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