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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/7314
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dc.contributor.authorSantos, Priscila Laíse dos-
dc.contributor.authorAraujo, Adriano Antunes de Souza-
dc.contributor.authorQuintans, Jullyana de Souza Siqueira-
dc.contributor.authorBrito, Renan Guedes de-
dc.contributor.authorSerafini, Mairim Russo-
dc.contributor.authorMenezes, Paula dos Passos-
dc.contributor.authorSantos, Márcio Roberto Viana dos-
dc.contributor.authorAlves, Péricles Barreto-
dc.contributor.authorLucca Júnior, Waldecy de-
dc.contributor.authorBlank, Arie Fitzgerald-
dc.contributor.authorLa Rocca, Viviana-
dc.contributor.authorAlmeida, Reinaldo Nobrega de-
dc.contributor.authorQuintans Júnior, Lucindo José-
dc.date.accessioned2018-02-05T18:33:17Z-
dc.date.available2018-02-05T18:33:17Z-
dc.date.issued2015-
dc.identifier.citationSANTOS, P. L. dos et al. Preparation, characterization, and pharmacological activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) leaf essential oil of B-cyclodextrin inclusion complexes. Evidence-Based Complementary and Alternative Medicine, v. 2015, 2015. Disponível em: <https://www.hindawi.com/journals/ecam/2015/502454/>. Acesso em: 05 fev. 2018.pt_BR
dc.identifier.issn1741-427X-
dc.identifier.urihttp://ri.ufs.br/jspui/handle/riufs/7314-
dc.languageengpt_BR
dc.publisherHindawi Publishing Corporationpt_BR
dc.relation.ispartofEvidence-Based Complementary and Alternative Medicinept_BR
dc.subjectCymbopogon winterianuseng
dc.subjectEssential oilseng
dc.subjectβ-cyclodextrineng
dc.subjectÓleos essenciaispor
dc.subjectβ-ciclodextrinapor
dc.titlePreparation, characterization, and pharmacological activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) leaf essential oil of B-cyclodextrin inclusion complexespt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição-Sem Derivações-Sem Derivados 3.0 Não Adaptada (CC BY-NC-ND 3.0)pt_BR
dc.description.resumoThis study aimed to evaluate the orofacial antinociceptive effect of the Cymbopogon winterianus essential oil (LEO) complexed in B-cyclodextrin (LEO-CD) and to assess the possible involvement of the central nervous system (CNS). The LEO was extracted, chromatographed, and complexed in B-cyclodextrin. The complex was characterized by differential scanning calorimetry (DSC) and thermogravimetry derivative (TG/DTG). Male Swiss mice (2-3 months) were treated with LEO-CD (50–200 mg/kg, p.o.), vehicle (distilled water, p.o.), or standard drug (i.p.) and subjected to the orofacial nociception formalin-, capsaicin-, and glutamateinduced. After the formalin test, the animals were perfused and the brains subjected to immunofluorescence for Fos. The rota-rod test (7 rpm/min) was carried out. Geraniol (37.57%) was the main compound of LEO. DSC and TG/DTG proved the complexation. The orofacial nociceptive behavior was significantly (p < 0.05) reduced. The number of Fos-positive cells was significantly changed in the dorsal raphe nucleus (p < 0.01), locus coeruleus (p < 0.001), trigeminal nucleus (p < 0.05), and trigeminal thalamic tract (p < 0.05). LEO-CD did not cause changes in motor coordination in the rota-rod test. Thus, our results suggested that LEO-CD has an orofacial antinociceptive profile, probably mediated by the activation of the CNS without changing the motor coordination.pt_BR
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