Reações adversas a medicamentos em gestantes internadas em uma unidade de alto risco na cidade de Aracaju/SE

Abstract

OBJECTIVE: To determine the prevalence of adverse drug reactions (ADRs) in women admitted to a service for high-risk pregnancy. METHODS: We conducted a cross-sectional study at Maternidade Nossa Senhora de Lourdes Aracaju / SE. The reference population consisted of all pregnant women admitted to the ward for high-risk study site with a live fetus, between the months of August and October 2011. Data were collected from clinical forms and evolution of nursing in addition to medical prescriptions and laboratory tests, daily, from the first day until discharge or transfer of patients. For identification of ADR was used an algorithm developed in this study. For confirmation of each ADR were applied the Naranjo algorithm and Korean Algorithm for ADR Causality Assessment - version 2.0. RESULTS: We included 294 patients, mostly aged between 20 and 30 years (44.90%), gestational age in the third quarter (79.59%). All patients had no previous pregnancy and most had a history of abortion (68.70%).39 (13.3%) patients experienced at least one ADR during hospitalization, with an average of 1.1 per patient ADR. It was observed influence of the age of the patient on the emergence ADR (p = 0.026), however, there were no associations between the the choice of drugs and the quantity of medicines by patients and the emergence of ADR (p = 0.239). CONCLUSION: Between variables was no significant association between ADR and age of patients. By associating the main drugs used by pregnant women and the emergence of ADR were not significantly associated.