Avaliação da incorporação de carregadores lipídicos nanoestruturados (CLNS) contendo hidroxiapatia em formulação creme

Abstract

The objective of this study was to evaluate the incorporation of nanostructured lipid carriers containing hydroxyapatite into cream formulation. Three formulations were obtained (F1-inert cream; F2- cream + nanocarrier; F3- cream + nanocarrier + hydroxyapatite). The physical stability of the cream, rheology, spreadability, occlusive effect and interaction with the stratum corneum model by DSC were evaluated. The stability results indicated that the studied formulations remained stable under the evaluated conditions. The formulations F1, F2 and F3 showed to be rheological behavior of non-Newtonian fluids with pseudoplastic flow and the flow index (n) of 0.20830±0.0001, 0.20270±0.0001, 0.20521±0.0001, desirable characteristic in formulations for application in the skin. For the spreadability, it was not noted any significant difference (p<0.005) between F2 and F3 formulations, however, when compared to F1, it was noted a significant difference (p>0.005). The occlusion test indicated that F2 and F3 formulation showed an increase in occlusive effect when compared to F1. DSC measurements indicated that the samples of stratum corneum treated with F2 and F3 showed the highest value of ΔH, suggesting greater water retention and a potential moisturizing effect. These results can present nanostructured lipid carrier containing the hydroxyapatite as a promising vehicle for cosmetic formulations of sun protection