Síntese e caracterização de nanocompósitos poliméricos de polipirrol/polissacarídeos naturais para aplicação como biomaterial

Abstract

The search for new biomaterials has been growing continuously in recent years and, in this context, the incorporation of polypyrrole (PPy) as a promising material for this function presents positive responses, highlighting its excellent bioactivity and biocompatibility for application in tissue engineering. The association of PPy with natural polysaccharides, highlighting xanthan gum, gellan and κcarrageenan, promotes a high potential for biomedical applications, besides, one of the advantages of using these polysaccharides, is its easy access and low processing cost. The present work had as main objective to synthesize and characterize nanocomposites based on PPy incorporated with natural polysaccharides, in order to improve the potential of polypyrrole as a threedimensional support in applications such as biomaterial. A preliminary comparative study was proposed to define the best methodology for the incorporation of gums, and from the results of XRD, FT-IR, TG, BET, SEM and TEM and biological analyzes, the methodology resulting from PPy II showed better results for incorporation of the gum, showing a difference only by incorporating the MO in the chosen synthesis, in addition to promoting a better dilution of the masses of the proportions of the gums to be studied. The production of nanocomposites from the chosen methodology provided a comparative study for the different concentrations of natural polysaccharides in relation to PPy. The results obtained from the nanocomposites in view of the most relevant physical-chemical analyzes such as FT-IR, TG, SEM and TEM showed a significant difference in relation to PPy alone for all analyzes performed. With the interest of knowing the susceptibility profile of nanocomposites to antimicrobial and cellular microorganisms, the bacteria Staphylococcus Aureus and Escherichia coli were submitted to the diffusion disc technique and obtained considerable halos in relation to the works of the literature. For cytotoxicity tests against fibroblastic cells (L929), all concentrations of the gums used were higher in terms of cell viability compared to the results of PPy II.