1. Repositório Institucional da Universidade Federal de Sergipe - RI/UFS
2. PRODUÇÃO CIENTÍFICA
3. DQI - Departamento de Química (São Cristóvão)
4. DQI - Artigos de periódicos

Document Type:	Artigo
Title:	Electrochemical and theoretical evaluation of the interaction between DNA and amodiaquine: evidence of the guanine adduct formation
Authors:	Arguelho, Maria de Lara Palmeira de Macedo Alves, José do Patrocínio Hora Stradiotto, Nelson Ramos Lacerda Júnior, Valdemar Pires, José Maria Beatriz, Adilson
Issue Date:	2010
Resumo :	The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.
Keywords:	Amodiaquine Guanine Adduct
ISSN:	0100-4042 1678-7064
Is part of:	Química Nova
Language:	eng
Publisher / Institution :	Sociedade Brasileira de Química
Citation:	ARGUELHO, M. L. P. M. et al. Electrochemical and theoretical evaluation of the interaction between DNA and amodiaquine: evidence of the guanine adduct formation. Química Nova, São Paulo, v. 33, n. 6, p. 1291-1296, 2010. Disponível em: https://www.scielo.br/j/qn/a/7VcfZzJtBJjzGrTSfCfbBFB/?format=pdf&lang=en. Acesso em: 14 mar. 2025.
License:	Creative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0)
URI:	https://ri.ufs.br/jspui/handle/riufs/21372
Appears in Collections:	DQI - Artigos de periódicos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.