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Tipo de Documento:	Artigo
Título :	Electrochemical and theoretical evaluation of the interaction between DNA and amodiaquine: evidence of the guanine adduct formation
Autor :	Arguelho, Maria de Lara Palmeira de Macedo Alves, José do Patrocínio Hora Stradiotto, Nelson Ramos Lacerda Júnior, Valdemar Pires, José Maria Beatriz, Adilson
Fecha de publicación :	2010
Resumen:	The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.
Palabras clave :	Amodiaquine Guanine Adduct
ISSN :	0100-4042 1678-7064
Es parte de:	Química Nova
Idioma :	eng
Institución / Editorial :	Sociedade Brasileira de Química
Citación :	ARGUELHO, M. L. P. M. et al. Electrochemical and theoretical evaluation of the interaction between DNA and amodiaquine: evidence of the guanine adduct formation. Química Nova, São Paulo, v. 33, n. 6, p. 1291-1296, 2010. Disponível em: https://www.scielo.br/j/qn/a/7VcfZzJtBJjzGrTSfCfbBFB/?format=pdf&lang=en. Acesso em: 14 mar. 2025.
License:	Creative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0)
URI :	https://ri.ufs.br/jspui/handle/riufs/21372
Aparece en las colecciones:	DQI - Artigos de periódicos

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