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Document Type:	Artigo
Title:	Amyotrophic lateral sclerosis: a focus on disease progression
Authors:	Calvo, Ana Cristina Manzano, Raquel Mendonça, Deise Maria Furtado de Muñoz, María J. Zaragoza, Pilar Osta, Rosario
Issue Date:	Aug-2014
Resumo :	Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a neurodegenerative disease in which motorneuron death is induced, a wide range of biomarkers have been selected to identify therapeutic targets. ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s diseases. However,the molecular targets that directly influence its aggressive nature remain unknown. What is the first link in the neurodegenerativechain of ALS that makes this disease so peculiar? In this review, we will discuss the progression of the disease from the viewpointof the potential biomarkers described to date in human and animal model samples. Finally, we will consider potential therapeuticstrategies for ALS treatment and future, innovative perspectives.
Keywords:	Amyotrophic lateral sclerosis Neurodegenerative diseases Disease progression Therapeutic strategies
ISSN:	2314-6141
Is part of:	BioMed Research International
Language:	eng
Publisher / Institution :	Hindawi Publishing Corporation
Citation:	CALVO, A. C. et al. Amyotrophic lateral sclerosis: a focus on disease progression. BioMed Research International, v. 2014, ago. 2014. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1155/2014/925101. Acesso em: 9 jan. 2026.
License:	Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)
URI:	https://ri.ufs.br/jspui/handle/riufs/24168
Appears in Collections:	DBCI - Artigos de periódicos

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