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Tipo de Documento:	Artigo
Título :	Amyotrophic lateral sclerosis: a focus on disease progression
Autor :	Calvo, Ana Cristina Manzano, Raquel Mendonça, Deise Maria Furtado de Muñoz, María J. Zaragoza, Pilar Osta, Rosario
Fecha de publicación :	2014
Resumen:	Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a neurodegenerative disease in which motorneuron death is induced, a wide range of biomarkers have been selected to identify therapeutic targets. ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s diseases. However,the molecular targets that directly influence its aggressive nature remain unknown. What is the first link in the neurodegenerativechain of ALS that makes this disease so peculiar? In this review, we will discuss the progression of the disease from the viewpointof the potential biomarkers described to date in human and animal model samples. Finally, we will consider potential therapeuticstrategies for ALS treatment and future, innovative perspectives.
Palabras clave :	Amyotrophic lateral sclerosis Neurodegenerative diseases Disease progression Therapeutic strategies
ISSN :	2314-6141
Es parte de:	BioMed Research International
Idioma :	eng
Institución / Editorial :	Hindawi Publishing Corporation
Citación :	CALVO, A. C. et al. Amyotrophic lateral sclerosis: a focus on disease progression. BioMed Research International, New York, n. 1, 2014. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1155/2014/925101. Acesso em: 9 jan. 2026.
License:	Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)
URI :	https://ri.ufs.br/jspui/handle/riufs/24168
Aparece en las colecciones:	DBCI - Artigos de periódicos

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