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https://ri.ufs.br/jspui/handle/riufs/25203| Document Type: | Artigo |
| Title: | Development and evaluation of stability ofa gel formulation containing the monoterpene borneol |
| Authors: | Dantas, Milla Gabriela Belarmino Reis, Silvio Alan Gonçalves Bomfim Damasceno, Camila Mahara Dias Rolim, Larissa Araújo Rolim Neto, Pedro José Carvalho, Ferdinando Oliveira Quintans Júnior, Lucindo José |
| Issue Date: | 2016 |
| Resumo : | Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional Chinese and Indian medicine. It is extracted from theessential oil of various medicinal plants. It has antibacterial, analgesic, and anti-inflammatory action proven in studies that used oraland intraperitoneal applications of this monoterpene in mice. The current study was designed to develop a topical gel formulationcontaining the monoterpene borneol using carbopol as gel base and to evaluate its stability. The prepared formulation was subjectedto physical characterization and physical-chemistry assessment. The gel was prepared from carbopol and 5% of borneol. Theprepared gel was subjected to pharmacotechnical tests such as its pH, viscosity, conductivity, spreadability, centrifugation, andaccelerated stability with freezing-thaw cycle. The borneol was successfully incorporated into the carbopol formulation. Borneolgel (BG5) showed good stability after eight months of its development and after 12 days in the freeze-thaw cycle, not showingstatistical difference in pH value, conductivity, and viscosity before and after test. Furthermore, the formulation showed a goodspreadability. Therefore, it was concluded that the formulation could be very promising alternative for the topical or transdermaltreatment of skin diseases. |
| Keywords: | Borneol Monoterpenoid alcohol Gel formulation |
| ISSN: | 1537-744X |
| Is part of: | The Scientific World Journal |
| Language: | eng |
| Citation: | DANTAS, M. G. B. et al. Development and evaluation of stability ofa gel formulation containing the monoterpene borneol. The Scientific World Journal, New York, n. 1, 2016. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2016/7394685. Acesso em: 3 jun. 2025. |
| License: | Creative Commons Atribuição 4.0 Internacional (CC BY 4.0) |
| Identifier: | https://doi.org/10.1155/2016/7394685 |
| URI: | https://ri.ufs.br/jspui/handle/riufs/25203 |
| Appears in Collections: | DFS - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| DevelopmentEvaluationStabilityGelFormulation.pdf | 151,38 kB | Adobe PDF |  View/Open |
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