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Document Type: Artigo
Title: Effect of green propolis on oral epithelial dysplasia in rats
Other Titles: Efeito da própolis verde sobre displasias epiteliais orais em ratos
Authors: Soares, Andrea Ferreira
Cavalcante, Danielle Rodrigues Ribeiro
Oliveira, Paula Santos de
Góis, Sandro Mota
Soares, Andrea Ferreira
Cardoso, Juliana Cordeiro
Padilha, Francine Ferreira
Albuquerque Júnior, Ricardo Luiz Cavalcanti de
Issue Date: Jun-2011
Abstract: Studies have demonstrated that flavonoid compounds of green propolis have antitumoral activity. Study Design: Experimental study. Aims: To evaluate the effect of a hydroalcoholic extract of green propolis (EPV) on chemically induced epithelial dysplasias in rat tongues. Methods and Materials: DMBA was brushed on the lingual dorsum of rats 3x/week on alternate days - 100 (PROP1), 200 (PROP2) and 300 mg/kg (PROP3) EPV was administered orally for 20 weeks. EPV or DMBA were replaced by their vehicles and applied as positive (TUM1 and TUM2) and negative controls (CTR1 and CTR2), respectively. The lingual epithelium was histologically analyzed and graded according a binary system and the WHO classification; the data were compared using ANOVA (*p<0.05). Results: The EPV yield was 41% and the flavonoid yield was 0.95±0.44%. According to the Binary System, TUM1, TUM2 and PROP1 were considered high risk lesions, with significantly higher morphological alteration rates compared to the other groups (p<0.05), which were considered low risk lesions. Based on the WHO classification, moderate dysplasia was TUM1 and TUM2, mild dysplasia was PROP1, PROP2 and PROP3, and non-dysplastic epithelium was CTR1 and CTR2. Conclusion: EPV seems to play an important protective role against chemically-induced lingual carcinogenesis in rats.
Keywords: 9,10-Dimetil-1,2- benzantraceno
Neoplasias bucais
Displasias epiteliais orais
ISSN: 1808-8694
Publisher / Institution : Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico Facial
Citation: CAVALCANTE, D. R. R. et al. Effect of green propolis on oral epithelial dysplasia in rats. Brazilian Journal of Otorhinolaryngology, São Paulo, v. 77, n. 3, p. 278-384, maio/jun. 2011. Disponível em: <>. Acesso em: 1 set. 2014.
License: Licença Creative Commons
Appears in Collections:DMO - Artigos de periódicos

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