Please use this identifier to cite or link to this item: http://ri.ufs.br/jspui/handle/riufs/1211
Document Type: Artigo
Title: Evidence for the Involvement of Spinal Cord-Inhibitory and Cytokines-Modulatory Mechanisms in the Anti-Hyperalgesic Effect of Hecogenin Acetate, a Steroidal Sapogenin-Acetylated, in Mice
Authors: Antoniolli, Ângelo Roberto
Quintans, Jullyana de Souza Siqueira
Barreto, Rosana de Souza Siqueira
Lucca Júnior, Waldecy de
Villarreal, Cristiane F.
Kaneto, Carla M.
Soares, Milena B. P.
Branco, Alexsandro
Almeida, Jackson Roberto Guedes da Silva
Taranto, Alex G.
Freitas, Rivelilson M.
Quintans-Júnior, Lucindo José
Issue Date: 19-Jun-2014
Abstract: Hecogenin is a steroidal sapogenin largely drawn from the plants of the genus Agave, commonly known as ‘sisal’, and is one of the important precursors used by the pharmaceutical industry for the synthesis of steroid hormones. Hecogenin acetate (HA) is a steroidal sapogenin-acetylated that produces antinociceptive activity. Thus, we evaluate the antihyperalgesic profile of HA in mice in inflammatory models, as well as its possible involvement with c-fos expression on spinal cord area and cytokines to produces analgesic profile. Acute pretreatment with HA (5, 10, or 20 mg/kg; i.p.) inhibited the development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine and PGE2. Additionally, the immunofluorescence data demonstrated that acute pretreatment with HA, at all doses tested, significantly inhibited Fos-like expression in the spinal cord dorsal horn normally observed after carrageenan-inflammation. Moreover, HA did not affect the motor performance of the mice as tested in the Rota rod test. This antinociceptive profile seems to be related, at least in part, to a reduction of pro-inflammatory cytokines, as IL-1β. The present results suggest that HA attenuates mechanical hyperalgesia by blocking the neural transmission of pain at the spinal cord levels and by cytokines-inhibitory mechanisms.
Keywords: Hecogenina etilo
Esteróide sapogenina
Espinal medula
C-fos
IL-1β
Dor
ISSN: 1420-3049
Publisher / Institution : MDPI - Open Access Publishing
Citation: QUINTANS, J. S. S. et. al. Evidence for the Involvement of Spinal Cord-Inhibitory and Cytokines-Modulatory Mechanisms in the Anti-Hyperalgesic Effect of Hecogenin Acetate, a Steroidal Sapogenin-Acetylated, in Mice. Molecules, v. 19, n. 6, 2014. Disponível em: <http://dx.doi.org/10.3390/molecules19068303>. Acesso em: 17 set. 2014.
License: Creative Commons Attribution License
URI: https://ri.ufs.br/handle/riufs/1211
Appears in Collections:DFS - Artigos publicados em periódicos

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