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Document Type: Artigo
Title: Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida
Authors: Dias, Antônio Santos
Martins, Marina Vieira
Estevam, Charles dos Santos
Santos, André Luiz Lima Menezes dos
Silva, Yolanda K. Cupertino da
Araújo Júnior, João Xavier
Miranda, Ana Luisa Palhares de
Barreiro, Eliezer Jesus de Lacerda
Pizza, Cosimo
Piacente, Sônia
Montoro, Paola
Quintans-Júnior, Lucindo José
Araujo, Brancilene Santos de
Moreira, Magna Suzana Alexandre
Santana, Antônio Euzébio Goulart
Issue Date: Jun-2012
Abstract: The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4'-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, ethyl acetate fraction, and 1. In the hot plate test, mice pretreated with 1 showed significantly increased reaction times (60-89%). Oral administration of 1 significantly inhibited first and second phases of the formalin-induced pain (50 and 26.5%, respectively), whereas indomethacin inhibited only the second phase of the test (41.2%). Ethanol extract and its fraction showed effects on inflammatory pain, while neurogenic and inflammatory pain suppression by 1 is a strong indication of the presence of both central and peripheral effects and suggests its analgesic and anti-inflammatory potential.
Keywords: Anti-inflamatório
Maytenus rígida
Extratos vegetais
4-metil epigalocatequina
ISSN: 0102-695X
Publisher / Institution : Sociedade Brasileira de Farmacognosia
Citation: MARTINS, M. V. et. al. Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 3, maio/jun. 2012. Disponível em: <>. Acesso em: 29 jan. 2015.
License: Creative Commons Attribution License
Appears in Collections:DFS - Artigos de periódicos

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