Use este identificador para citar ou linkar para este item: http://ri.ufs.br/jspui/handle/riufs/1414
Tipo de Documento: Artigo
Título: Abarema cochliacarpos extract decreases the inflammatory process and skeletal muscle injury induced by bothrops leucurus venom
Autor(es): Dias, Antônio Santos
Oliveira, Jeison Saturnino de
Santos, Daiana do Carmo
Guimarães, Adriana Gibara
Tomaz, Marcelo Amorim
Machado, Marcos Monteiro
Estevam, Charles dos Santos
Lucca Júnior, Waldecy de
Maria, Durvanei Augusto
Melo, Paulo de Assis
Araújo, Adriano Antunes de Souza
Santos, Márcio Roberto Viana dos
Almeida, Jackson Roberto Guedes da Silva
Oliveira, Rita de Cássia Meneses
Oliveira, Aldeidia Pereira de
Quintans-Júnior, Lucindo José
Data do documento: 2014
Abstract: Snakebites are a public health problem, especially in tropical countries.However, treatment with antivenomhas limited effectiveness against venoms’ local effects. Here, we investigated the ability of Abarema cochliacarpos hydroethanolic extract (EAc) to protect mice against injection of Bothrops leucurus venom. Swiss mice received perimuscular venom injection and were subsequently treated orally with EAc in different doses. Treatment with EAc 100, 200, and 400mg/kg reduced the edema induced by B. leucurus in 1%, 13%, and 39%, respectively. Although lower doses showed no antihypernociceptive effect in the Von Frey test, the higher dose significantly reduced hyperalgesia induced by the venom. Antimyotoxic activity of EAc was also observed by microscopy assessment, with treated muscles presenting preserved structures, decreased edema, and inflammatory infiltrate as compared to untreated ones. Finally, on the rotarod test, the treated mice showed better motor function, once muscle fibers were preserved and there were less edema and pain. Treated mice could stand four times more time on the rotating rod than untreated ones. Our results have shown that EAc presented relevant activities against injection of B. leucurus venom in mice, suggesting that it can be considered as an adjuvant in the treatment of envenomation.
Palavras-chave: Extratos vegetais
Abarema cochliacarpos
Abaremo-temo
Bothrops leucurus
Doenças musculares
ISSN: 2314-6141
Instituição/Editora: Hindawi Publishing Corporation
Citação: OLIVEIRA, J. S. et. al. Abarema cochliacarpos Extract Decreases the Inflammatory Process and Skeletal Muscle Injury Induced by Bothrops leucurus Venom. BioMed Research International, v. 2014, 2014. Disponível em: <http://dx.doi.org/10.1155/2014/820761>. Acesso em: 29 jan. 2015.
Licença: Creative Commons Attribution License
URI: https://ri.ufs.br/handle/riufs/1414
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