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Document Type: Artigo
Title: Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions
Authors: Dias, Antônio Santos
Santos, Clisiane Carla de Souza
Araujo, Silvan Silva de
Santos, André Luiz Lima Menezes dos
Almeida, Elis Cristiane Valença de
Damascena, Nicole Prata
Santos, Deisylaine Maria dos
Santos, Matheus Ismerim Silva
Ribeiro Júnior, Karlos Antônio Lisboa
Pereira, Carla Karine Barbosa
Lima, Amanda do Carmo Bion de
Shan, Andrea Yu Kwan Villar
Santana, Antônio Euzébio Goulart
Estevam, Charles dos Santos
Araujo, Brancilene Santos de
Issue Date: Jun-2014
Abstract: Dengue fever and schistosomiasis are major public health issues for which vector control using larvicide and molluscicide substances present in plants provides a promising strategy. This study evaluated the potential toxicity of the extract of hydroethanol Schinopsis brasiliensis Engl., Anacardiaceae, stem bark and its chloroform, hexane, ethyl acetate, and hydromethanol fractions against Artemia salina and Aedes Aegypti larvae and snails Biomphalaria glabrata. All of the assays were performed in triplicate and the mean mortality rates were used to determine the LC50 and LC90 values using the probit method. The hydroethanol hydromethanol extract and fraction were free of toxicity towards A. salina (LC50 > 1000 µg/ml), while chloroform fraction was moderately toxic (LC50 313 µg/ml); ethyl acetate and hexane fractions displayed low toxicity, with LC50 557 and 582 µg/ml, respectively. Chloroform, hexane, and ethyl acetate fractions showed larvicidal potential towards A. aegypti (LC50 values of 345, 527 and 583 µg/ml, respectively), while chloroform and ethyl acetate fractions were highly toxic to B. glabrata (LC90 values of 68 and 73 µg/ml, respectively). Based on these findings, ethyl acetate, chloroform, and hexane fractions should be further investigated for their potential use against the vectors of dengue and schistosomiasis.
Keywords: Artemia salina
Erythrina velutina
Schinopsis brasiliensis
ISSN: 0102-695X
Publisher / Institution : Sociedade Brasileira de Farmacognosia
Citation: SANTOS, C. C. S. et. al. Evaluation of the toxicity and molluscicidal and larvicidal activities of Schinopsis brasiliensis stem bark extract and its fractions. Revista Brasileira de Farmacognosia, Curitiba, v. 24, n. 3, maio/jun. 2014. Disponível em: <>. Acesso em: 29 jan. 2015.
License: Creative Commons Attribution License
Appears in Collections:DFS - Artigos de periódicos

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