Please use this identifier to cite or link to this item: http://ri.ufs.br/jspui/handle/riufs/1506
Document Type: Artigo
Title: Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii
Authors: Melo, Marcelia Garcez Dória de
Araújo, Adriano Antunes de Souza
Rocha, Carla Paula Leite
Almeida, Emyle Mayra Santana Alves
Siqueira, Rosana de Souza
Bonjardim, Leonardo Rigoldi
Quintans-Júnior, Lucindo José
Issue Date: Oct-2008
Abstract: Lichens and their secondary metabolites have attracted the interest of many researchers. Some species have been shown to contain substances with remarkable biologic activity, as antimicrobial, mainly against Gram positive bacteria; antineoplasic acting on solid and ascetic tumors, or in culture cells; antiviral; hypotensive; and spasmolytic effects. The aim of this study was to isolate and characterize atranorin, one of the major constituents which presents in Cladina kalbii (DES ABB.) AHTI., and analyze its antinociceptive effect. The antinociceptive activity was verified in acetic acid-induced writhing test and formalin test with mice. In this work it was observed that atranorin was effective in significant reducing (p<0.05) abdominal writhing at doses of 200 and 400 mg/kg (p.o.) by 52.6 and 61.3%, respectively, when compared to control group (vehicle). The formalin test showed in 200 and 400 mg/kg (p.o.) that atranorin injection was able to inhibit the inflammatory processes (second phase) dose dependently.
Keywords: Cladina kalbii
Atividade antinociceptiva
Análise térmica
Atranorina
ISSN: 1347-5215
Publisher / Institution : The Pharmaceutical Society of Japan
Citation: MELO, M. G. D. et al. Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii. Biological & Pharmaceutical Bulletin, Sapporo, v. 31, p. 1977-1980, out. 2008. Disponível em: <https://www.jstage.jst.go.jp/article/bpb/31/10/31_10_1977/_article>. Acesso em: 12 jun. 2013.
URI: https://ri.ufs.br/handle/riufs/1506
Appears in Collections:DFA - Artigos publicados em periódicos

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