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https://ri.ufs.br/jspui/handle/riufs/1751
Document Type: | Artigo |
Title: | Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis |
Authors: | Burgos, Ursula Maria Moreira Costa Oliveira, Carla Raquel Pereira Salvatori, Roberto Barreto Filho, José Augusto Soares Campos, Viviane Correia Oliveira, Francielle Temer de Rocha, Ívina Elaine dos Santos Oliveira, Joselina Luzia Menezes Silva, Wersley Araújo Oliveira, Manuel Herminio de Aguiar |
Issue Date: | Jan-2016 |
Abstract: | GH and its principal mediator IGF1 have important effects on metabolic and cardiovascular (CV) status. While acquired GH deficiency (GHD) is often associated with increased CV risk, the consequences of congenital GHD are not known. We have described a large group of patients with isolated GHD (IGHD) due to a homozygous mutation (c.57C1GOA) in the GH releasing hormone receptor gene, and shown that adult GH-naı¨ve individuals have no evidence of clinically evident premature atherosclerosis. To test whether subclinical atherosclerosis is anticipated in untreated IGHD, we performed a cross-sectional study of 25 IGHD and 27 adult controls matched for age and gender. A comprehensive clinical and biochemical panel and coronary artery calcium scores were evaluated by multi-detector tomography. Height, weight, IGF1, homeostasis model assessment of insulin resistance, creatinine and creatininekinase were lower in the IGHD group. Median and interquartile range of calcium scores distribution was similar in the two groups: IGHD 0(0) and control 0(4.9). The vast majority of the calcium scores (20 of 25 IGHD (80%) and 18 of 27 controls (66.6%)) were equal to zero (difference not significant). There was no difference in the calcium scores classification. None of IGHD subjects had minimal calcification, which were present in four controls. Three IGHD and four controls had mild calcification. There were two IGHD individuals with moderate calcification and one control with severe calcification. Our study provides evidence that subjects with congenital isolated lifetime and untreated severe IGHD do not have accelerated subclinical coronary atherosclerosis. |
Keywords: | Coronary atherosclerosis Aterosclerose coronária Isolated growth hormone deficiency Calcium score Multi-detector CT |
ISSN: | 2049-3614 |
Publisher / Institution : | Bioscientifica |
Citation: | BURGOS, U. M. M. C. et al. Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis. Endocrine Connections, v. 5, n. 1, jan. 2016. Disponível em: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738236/>. Acesso em: 11 abr. 2016. |
License: | Creative Commons Attribution-NonCommercial 4.0 International License |
URI: | https://ri.ufs.br/handle/riufs/1751 |
Appears in Collections: | DME - Artigos de periódicos |
Files in This Item:
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GHDeficiencyAtherosclerosis.pdf | 223,11 kB | Adobe PDF | ![]() View/Open |
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