Use este identificador para citar ou linkar para este item: http://ri.ufs.br/jspui/handle/riufs/1751
Tipo de Documento: Artigo
Título: Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis
Autor(es): Burgos, Ursula Maria Moreira Costa
Oliveira, Carla Raquel Pereira
Salvatori, Roberto
Barreto Filho, José Augusto Soares
Campos, Viviane Correia
Oliveira, Francielle Temer de
Rocha, Ivina Elaine dos Santos
Oliveira, Joselina Luzia Menezes
Silva, Wersley Araújo
Oliveira, Manuel Herminio de Aguiar
Data do documento: Jan-2016
Abstract: GH and its principal mediator IGF1 have important effects on metabolic and cardiovascular (CV) status. While acquired GH deficiency (GHD) is often associated with increased CV risk, the consequences of congenital GHD are not known. We have described a large group of patients with isolated GHD (IGHD) due to a homozygous mutation (c.57C1GOA) in the GH releasing hormone receptor gene, and shown that adult GH-naı¨ve individuals have no evidence of clinically evident premature atherosclerosis. To test whether subclinical atherosclerosis is anticipated in untreated IGHD, we performed a cross-sectional study of 25 IGHD and 27 adult controls matched for age and gender. A comprehensive clinical and biochemical panel and coronary artery calcium scores were evaluated by multi-detector tomography. Height, weight, IGF1, homeostasis model assessment of insulin resistance, creatinine and creatininekinase were lower in the IGHD group. Median and interquartile range of calcium scores distribution was similar in the two groups: IGHD 0(0) and control 0(4.9). The vast majority of the calcium scores (20 of 25 IGHD (80%) and 18 of 27 controls (66.6%)) were equal to zero (difference not significant). There was no difference in the calcium scores classification. None of IGHD subjects had minimal calcification, which were present in four controls. Three IGHD and four controls had mild calcification. There were two IGHD individuals with moderate calcification and one control with severe calcification. Our study provides evidence that subjects with congenital isolated lifetime and untreated severe IGHD do not have accelerated subclinical coronary atherosclerosis.
Palavras-chave: Coronary atherosclerosis
Aterosclerose coronária
Isolated growth hormone deficiency
Calcium score
Multi-detector CT
ISSN: 2049-3614
Instituição/Editora: Bioscientifica
Citação: BURGOS, U. M. M. C. et al. Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis. Endocrine Connections, v. 5, n. 1, jan. 2016. Disponível em: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738236/>. Acesso em: 11 abr. 2016.
Licença: Creative Commons Attribution-NonCommercial 4.0 International License
URI: https://ri.ufs.br/handle/riufs/1751
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