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Document Type: Artigo
Title: Lifetime congenital isolated GH deficiency does not protect from the development of diabetes
Authors: Vicente, Tábita de Almeida Ribeiro
Rocha, Ivina Elaine dos Santos
Salvatori, Roberto
Oliveira, Carla Raquel Pereira
Pereira, Rossana Maria Cahino
Souza, Anita Herminia Oliveira
Campos, Viviane Correia
Santos, Elenilde Gomes
Araujo, Rachel Diniz Correia de
Valença, Eugenia Herminia Oliveira
Pereira, Carlos de Carvalho Epitácio
Oliveira, Mario C. P.
Mari, Andrea
Oliveira, Manuel Herminio de Aguiar
Issue Date: Jun-2013
Abstract: Objectives: Adult subjects with untreated, lifetime, isolated GH deficiency (IGHD) due to a homozygous GHRH receptor gene mutation (MUT/MUT) residing in Itabaianinha, Brazil, present with lower BMI, higher prevalence of impaired glucose tolerance (IGT), increased insulin sensitivity (IS), and reduced β-cell function (βCF) when compared with non-BMI-matched homozygous normal controls. However, the prevalence of diabetes mellitus (DM) in this cohort is unknown. Comparing their IS and βCF with BMI-matched individuals heterozygous for the same mutation (MUT/N) may be useful to elucidate the role of the GH–IGF1 axis in IS and βCF. The purposes of this work were to verify the prevalence of IGT and DM in adult MUT/MUT subjects from this kindred and to compare IS and βCF in MUT/MUT and MUT/N. Design: Cross-sectional study. Methods: We studied most (51) of the living IGHD adults of this kindred who are GH naive. The oral glucose tolerance test (OGTT) could be performed in 34 subjects, fasting glucose was measured in 15, while two had a previous diagnosis of DM. The OGTT results of 24 MUT/MUT subjects were compared with those of 25 BMI-matched MUT/N subjects. IS was assessed by homeostatic model assessment of insulin resistance (HOMA–IR), quantitative IS check index, and oral glucose IS index for 2 and 3 h. βCF was assayed by HOMA-β, insulinogenic index, and the area under the curve of insulin:glucose ratio. Results The prevalence of DM and IGT in IGHD was 15.68 and 38.23% respectively. IS was increased and βCF was reduced in MUT/MUT in comparison with MUT/N. Conclusions: Lifetime, untreated IGHD increases IS, impairs βCF, and does not provide protection from diabetes.
Keywords: Insulin sensitivity
β-cell function
GH deficiency
Sensibilidade à insulina
Deficiência de GH
ISSN: 2049-3614
Publisher / Institution : Bioscientifica
Citation: VICENTE, T. A. R. et al. Lifetime congenital isolated GH deficiency does not protect from the development of diabetes. Endocrine Connections, v. 2, n. 2, jun. 2013. Disponível em: <>. Acesso em: 13 abr. 2016.
License: Creative Commons Attribution 3.0 Unported License
Appears in Collections:DME - Artigos publicados em periódicos

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