Please use this identifier to cite or link to this item: http://ri.ufs.br/jspui/handle/riufs/1809
Document Type: Artigo
Title: Absorption levels and morphological features of fetal organs in wistar rats treated with lead acetate
Other Titles: Niveles de absorción y características morfológicas de los órganos fetales en ratas wistar tratadas con acetato de plomo
Authors: Bomfim, Kátia Michelle dos Anjos
Garcia, Carlos Alexandre Borges
Reis, Francisco Prado
Palmeira, José Arnaldo Vasconcelos
Scher, Ricardo
Lucca Júnior, Waldecy de
Aragão, José Adeval
Vasconcelos, Francis Lima
Albuquerque Júnior, Ricardo Luiz Cavalcanti de
Feitosa, Vera Lúcia Corrêa
Issue Date: Mar-2012
Abstract: Lead is one of the heavy metals most used in industry. Poisoning due to long-term lead exposure is known as saturnism, and is an occupational illness that has been known for many years. Lead is highly toxic and can compromise the structural and functional patterns of organs and systems. The aim of this study was to examine the lungs and kidneys of fetuses from female Wistar rats exposed to lead acetate. In this study, the lungs and kidneys of 20 fetuses from female rats that had previously been treated with lead acetate were dissected, fixed, embedded in paraffin and stained with hematoxylin and eosin. Macroscopic changes to the shape, color and consistency of organs from fetuses treated with this heavy metal were observed, in comparison with organs from control fetuses. Microscopic lesions characterized by vascular sclerosis, cell atrophy or hyperplasia, progressive interstitial fibrosis, inclusion bodies containing lead acetate and glomerular sclerosis were found in the kidneys. The lesions found in the lungs consisted of destructuring of the parenchyma, impregnation with lead acetate, formation of fibrosis, extravasation of vascular fluids, reduction of the alveolar spaces and formation of alveolar edema. These changes were correlated with the level of lead acetate absorption, as determined using atomic spectrophotometry._________________________________________________________________________________________ RESUMEN: El plomo es un metal pesado utilizado en la industria. El envenenamiento debido a la exposición prolongada por plomo es una enfermedad profesional conocida por muchos años. La toxicidad del plomo es muy expresiva y puede poner en peligro el modelo estructural y funcional de los órganos y sistemas. El objetivo de este estudio fue examinar los pulmones y riñones de fetos de ratas Wistar expuestos al acetato de plomo. En este estudio, 20 fetos de ratas Wistar previamente tratados con acetato de plomo durante la gestación, tuvieron sus órganos disecados, fijados, incluidos en parafina y teñidos con hematoxilina y eosina. Macroscópicamente, los órganos fetales tratados por este metal fueron comparados con los órganos de fetos controles en relación a forma, color y consistencia. Microscópicamente, se encontraron lesiones en el riñón que se caracterizaron por esclerosis vascular, atrofia o hiperplasia de células, fibrosis intersticial progresiva, presencia de cuerpos de inclusión que contenían acetato de plomo y esclerosis glomerular. En el pulmón se observó desorganización del parénquima impregnado con acetato de plomo, formación de fibrosis, líquido intersticial, reducción de los espacios alveolares y edema alveolar. Estos cambios se correlacionaron con el nivel de absorción de acetato de plomo, determinado por espectrometría atómica.
Keywords: Química
Acetato de chumbo
Fetos
Pulmão
Rim
Acetato de plomo
Pulmón
Riñon
Lead acetate
Fetuses
Lung
Kidney
ISSN: 0717-9502
Publisher / Institution : Sociedad Chilena de Anatomía
Citation: BOMFIM, K. M. A. et al. Absorption levels and morphological features of fetal organs in wistar rats treated with lead acetate. International Journal of Morphology, Temuco, v. 30, n. 1, p. 119-124, mar. 2012. Disponível em: <http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100021&lng=pt&nrm=iso>. Acesso em 25 jul. 2016.
License: Creative Commons Atribuição-NãoComercial 4.0 Internacional
URI: https://ri.ufs.br/handle/riufs/1809
Appears in Collections:DQI - Artigos publicados em periódicos

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