Desenvolvimento de membrana polimérica contendo extrato das folhas de libidibia ferrea (Mart. ex Tul.) L.P. Queiroz para o tratamento de feridas cutâneas

Abstract

Introduction: Polymeric membranes have gained prominence as a promising alternative for the treatment of skin wound. The chitosan polymer is used to develop biodegradable and renewable membranes that can serve as temporary dressings and allow the incorporation of active ingredients. Libidibia ferrea has antibacterial and anti-inflammatory action and has been used in pharmaceutical formulations for this purpose. Objective: To develop polymeric membranes incorporated with extracts of Libidibia ferrea for the treatment of skin wounds. Methods: The extracts were obtained by maceration and ultrasound extraction methods, being subjected to tests: phytochemical screening, quantification of phenolic compounds, and flavonoids. The membranes were produced using the method described by Pereira (2021) and evaluated by phytochemical quality control: content of phenolic compounds and flavonoids released by the membrane containing Libidibia ferrea extract. Results: The extracts contained flavonoids, triterpenoids, and saponins, with no presence of coumarins identified. The extraction yield was 9.82% for the ultrasound method and 22.12% for dynamic maceration. Quantification of metabolites showed flavonoid content (374.25 ± 30.05 µg/mL) and phenolic compounds (496.76 ± 24.01 µg/mL) in the ultrasound-assisted extract. The membranes released metabolites from their matrix structure with a higher content of phenolic compounds (26.76 ± 2.67 µg/mL). Conclusion: The membrane containing Libidibia ferrea may be a new alternative for treating wounds or burns